Gene Page: PRTN3

Summary
GeneID  5657
Symbol  PRTN3
Synonyms  ACPA|AGP7|C-ANCA|MBT|P29|PR-3
Description  proteinase 3
See related  HGNC:9495|MIM:177020|Ensembl:ENSG00000196415|HPRD:01512|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.6269 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ATP5O0.900.91
BUD310.890.91
PSMB30.880.88
ATP5L0.870.87
C11orf730.870.87
COMMD10.860.85
ZNHIT30.860.88
PSMB40.860.87
RBX10.860.87
PSMA50.850.86
Top 10 negatively co-expressed genes
AF347015.26-0.60-0.63
AF347015.15-0.58-0.59
AF347015.2-0.57-0.59
AF347015.8-0.57-0.57
MT-ATP8-0.56-0.59
AF347015.18-0.56-0.61
AF347015.33-0.54-0.56
MT-CYB-0.53-0.56
AF347015.27-0.53-0.55
EPAS1-0.52-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0005515protein bindingIPI15527767 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0008284positive regulation of cell proliferationTAS2598267 
GO:0030574collagen catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0043231intracellular membrane-bounded organelleIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAMPCAP18 | CRAMP | FALL-39 | FALL39 | HSD26 | LL37cathelicidin antimicrobial peptide-HPRD11389039 
ELNFLJ38671 | FLJ43523 | SVAS | WBS | WSelastin-HPRD,BioGRID11867344 
IL1BIL-1 | IL1-BETA | IL1F2interleukin 1, beta-HPRD,BioGRID10339575 
ITGAMCD11B | CR3A | MAC-1 | MAC1A | MGC117044 | MO1A | SLEB6integrin, alpha M (complement component 3 receptor 3 subunit)Affinity Capture-WesternBioGRID12960243 
ITGB2CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)-HPRD12960243 
SERPINA1A1A | A1AT | AAT | MGC23330 | MGC9222 | PI | PI1 | PRO2275serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Biochemical ActivityBioGRID12114510 
SERPINB1EI | ELANH2 | LEI | M/NEI | MNEI | PI2serpin peptidase inhibitor, clade B (ovalbumin), member 1-HPRD,BioGRID12114510 
-HPRD7654387 
SERPINB13HSHUR7SEQ | HUR7 | MGC126870 | PI13 | headpinserpin peptidase inhibitor, clade B (ovalbumin), member 13-HPRD10512713 
TNFDIF | TNF-alpha | TNFA | TNFSF2tumor necrosis factor (TNF superfamily, member 2)-HPRD,BioGRID10339575 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_UP 4424All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP 3124All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP 7049All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA1_UP 10166All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
KAMIKUBO_MYELOID_CEBPA_NETWORK 2819All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway


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