Gene Page: PSMC3

Summary
GeneID  5702
Symbol  PSMC3
Synonyms  MGC8487|TBP1
Description  proteasome (prosome, macropain) 26S subunit, ATPase, 3
See related  HGNC:9549|MIM:186852|Ensembl:ENSG00000165916|HPRD:01733|
Locus tag  -
Gene type  protein-coding
Map location  11p12-p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.01 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TNFAIP8L30.610.52
WNT5A0.580.51
NR3C20.570.61
PKP20.560.51
NEUROD10.540.32
NRP10.540.46
BNC10.530.21
DUSP0.520.35
MATN20.520.60
C1QTNF30.520.24
Top 10 negatively co-expressed genes
AC098691.2-0.24-0.28
AF347015.21-0.23-0.20
MT-CO2-0.21-0.18
PLA2G5-0.21-0.15
AF347015.18-0.21-0.22
AF347015.8-0.21-0.17
CLEC2B-0.19-0.17
IL32-0.19-0.20
MT-CYB-0.19-0.15
AF347015.33-0.19-0.13
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003713transcription coactivator activityTAS8419915 
GO:0003714transcription corepressor activityTAS2194290 
GO:0005515protein bindingIPI17220478 |17353931 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0017111nucleoside-triphosphatase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001824blastocyst developmentIEA-
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processEXP11285280 
GO:0030163protein catabolic processIEA-
GO:0044419interspecies interaction between organismsIEA-
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP15029244 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000502proteasome complexTAS8811196 
GO:0005829cytosolIEA-
GO:0005634nucleusTAS2194290 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)p14ARF interacts with TBP-1.BIND14665636 
EPAS1ECYT4 | HIF2A | HLF | MOP2 | PASD2endothelial PAS domain protein 1Affinity Capture-WesternBioGRID14556007 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD,BioGRID14556007 
HTR1E5-HT1E5-hydroxytryptamine (serotonin) receptor 1EAffinity Capture-MSBioGRID17353931 
PAAF1FLJ11848 | PAAF | Rpn14 | WDR71proteasomal ATPase-associated factor 1Affinity Capture-MSBioGRID17353931 
PSMC3MGC8487 | TBP1proteasome (prosome, macropain) 26S subunit, ATPase, 3-HPRD11463857 
PSMC3IPGT198 | HOP2 | HUMGT198A | TBPIPPSMC3 interacting protein-HPRD9345291 
PSMC4MGC13687 | MGC23214 | MGC8570 | MIP224 | S6 | TBP7proteasome (prosome, macropain) 26S subunit, ATPase, 4Affinity Capture-MSBioGRID17353931 
-HPRD11463857 
PSMC5S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUGproteasome (prosome, macropain) 26S subunit, ATPase, 5-HPRD,BioGRID11463857 
PSMD10dJ889N15.2 | p28proteasome (prosome, macropain) 26S subunit, non-ATPase, 10Affinity Capture-MSBioGRID17353931 
PSMD13HSPC027 | Rpn9 | S11 | p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13Affinity Capture-MSBioGRID17353931 
PSMD6KIAA0107 | Rpn7 | S10 | SGA-113M | p44S10proteasome (prosome, macropain) 26S subunit, non-ATPase, 6Affinity Capture-MSBioGRID17353931 
STX11FHL4 | HLH4 | HPLH4syntaxin 11Two-hybridBioGRID16169070 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6Affinity Capture-MSBioGRID14743216 
TXNRD2SELZ | TR | TR-BETA | TR3 | TRXR2thioredoxin reductase 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11463857 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressor-HPRD,BioGRID14556007 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PROTEASOME 4828All SZGR genes in this pathway
BIOCARTA_PROTEASOME_PATHWAY 2819All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES 4829All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_ER_PHAGOSOME_PATHWAY 6140All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 5131All SZGR genes in this pathway
REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 4827All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC 4933All SZGR genes in this pathway
REACTOME_REGULATION_OF_APOPTOSIS 5834All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 5735All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION 8145All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 5631All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 5130All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 8546All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 6536All SZGR genes in this pathway
REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 8450All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 5331All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 7238All SZGR genes in this pathway
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 7340All SZGR genes in this pathway
REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C 6434All SZGR genes in this pathway
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 5132All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 5230All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_DN 3524All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
WHITEHURST_PACLITAXEL_SENSITIVITY 3919All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
LEE_AGING_MUSCLE_DN 4629All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_UP 212128All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
LI_DCP2_BOUND_MRNA 8957All SZGR genes in this pathway


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