Gene Page: RTN4

Summary
GeneID  57142
Symbol  RTN4
Synonyms  ASY|NI220/250|NOGO|NOGO-A|NOGOC|NSP|NSP-CL|Nbla00271|Nbla10545|Nogo-B|Nogo-C|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Description  reticulon 4
See related  HGNC:14085|MIM:604475|Ensembl:ENSG00000115310|HPRD:07259|
Locus tag  -
Gene type  protein-coding
Map location  2p16.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11126360 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030517negative regulation of axon extensionIDAaxon (GO term level: 15)10667797 
GO:0019987negative regulation of anti-apoptosisIMP11126360 
GO:0042981regulation of apoptosisNAS11126360 
GO:0030334regulation of cell migrationIDA15034570 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005635nuclear envelopeIDA11126360 
GO:0005783endoplasmic reticulumIEA-
GO:0005783endoplasmic reticulumNAS11126360 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0030176integral to endoplasmic reticulum membraneIDA10667797 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2Bcl-2B-cell CLL/lymphoma 2RTN-XS interacts with Bcl-2.BIND11126360 
-HPRD,BioGRID11126360 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID11126360 
RTN-XS interacts with Bcl-XL.BIND11126360 
CNTNAP1CASPR | CNTNAP | NRXN4 | P190contactin associated protein 1-HPRD,BioGRID14592966 
COL4A3BPCERT | CERTL | FLJ20597 | GPBP | STARD11collagen, type IV, alpha 3 (Goodpasture antigen) binding proteinTwo-hybridBioGRID16189514 
CRMP1DPYSL1 | DRP-1 | DRP1collapsin response mediator protein 1Two-hybridBioGRID16169070 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
KCNA1AEMK | EA1 | HBK1 | HUK1 | KV1.1 | MBK1 | MGC126782 | MGC138385 | MK1 | RBK1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)Affinity Capture-WesternBioGRID14592966 
KCNA2HBK5 | HK4 | HUKIV | KV1.2 | MGC50217 | MK2 | NGK1 | RBK2potassium voltage-gated channel, shaker-related subfamily, member 2Affinity Capture-WesternBioGRID14592966 
LRCH4FLJ40101 | FLJ46315 | LRN | LRRN1 | LRRN4 | PP14183 | SAP25leucine-rich repeats and calponin homology (CH) domain containing 4Two-hybridBioGRID16189514 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1Two-hybridBioGRID16169070 
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaTwo-hybridBioGRID16189514 
PLEKHF2FLJ13187 | PHAFIN2 | ZFYVE18pleckstrin homology domain containing, family F (with FYVE domain) member 2Two-hybridBioGRID16189514 
PRR13DKFZp564J157 | FLJ23818 | TXR1proline rich 13Two-hybridBioGRID16169070 
RAB33AMGC1488 | RabS10RAB33A, member RAS oncogene familyTwo-hybridBioGRID16189514 
RTN3ASYIP | HAP | NSPL2 | NSPLII | RTN3-A1reticulon 3Two-hybridBioGRID16189514 
RTN4IP1MGC12934 | NIMPreticulon 4 interacting protein 1-HPRD,BioGRID12067236 
Nogo-A interacts with NIMP.BIND12067236 
RTN4RNGR | NOGORreticulon 4 receptor-HPRD11201742 
Nogo-66 interacts with NgR.BIND15694321 
SIRT2SIR2 | SIR2L | SIR2L2sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
SPG21ACP33 | BM-019 | GL010 | MASPARDIN | MASTspastic paraplegia 21 (autosomal recessive, Mast syndrome)Two-hybridBioGRID16189514 
UQCRC1D3S3191 | QCR1 | UQCR1ubiquinol-cytochrome c reductase core protein INogo-A interacts with UQCRC1.BIND12067236 
-HPRD,BioGRID12067236 
UQCRC2QCR2 | UQCR2ubiquinol-cytochrome c reductase core protein IINogo-A interacts with UQCRC2.BIND12067236 
-HPRD,BioGRID12067236 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_DN 9251All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN 4529All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_3 2816All SZGR genes in this pathway
LUI_TARGETS_OF_PAX8_PPARG_FUSION 3423All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_DN 87All SZGR genes in this pathway
PETRETTO_CARDIAC_HYPERTROPHY 3426All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_DN 8556All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
TERAO_AOX4_TARGETS_SKIN_UP 3827All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GUILLAUMOND_KLF10_TARGETS_DN 3015All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/2125095151Ahsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-1538408461Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-182522528m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-218649655m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-4488408461Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4556516571Ahsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-4915946001Ahsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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