Gene Page: LRRC7

Summary
GeneID  57554
Symbol  LRRC7
Synonyms  DKFZp686I1147|KIAA1365|MGC144918
Description  leucine rich repeat containing 7
See related  HGNC:18531|Ensembl:ENSG00000033122|HPRD:09930|
Locus tag  -
Gene type  protein-coding
Map location  1p31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02692 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EDC30.950.94
WDR50.950.95
GTF3C20.950.95
KIAA19670.950.95
QRICH10.950.94
LSM14B0.950.95
FAM40A0.950.94
PRCC0.940.94
USP100.940.94
SF10.940.94
Top 10 negatively co-expressed genes
MT-CO2-0.83-0.90
AF347015.31-0.82-0.89
AF347015.27-0.80-0.88
AF347015.33-0.80-0.86
MT-CYB-0.79-0.86
FXYD1-0.79-0.87
AF347015.8-0.78-0.88
IFI27-0.77-0.84
C5orf53-0.76-0.77
AF347015.21-0.76-0.92
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI15767459 |17353931 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionIDA18029348 
GO:0005886plasma membraneIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN4ACTININ-4 | DKFZp686K23158 | FSGS | FSGS1actinin, alpha 4-HPRD11160423 
LRRC7 (Densin-180) interacts with ACTN4 (alpha-Actinin 4). This interaction was modeled on a demonstrated interaction between rat LRCC7 and human ACTN4.BIND11160423 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alpha-HPRD11160423 
LRRC7 (Densin-180) interacts with CAMK2A (CaMKII-alpha). This interaction was modeled on a demonstrated interaction between rat LRCC7 and human CAMK2A.BIND11160423 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)-HPRD,BioGRID11729199 
CNKSR2CNK2 | KIAA0902 | KSR2connector enhancer of kinase suppressor of Ras 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12390249 
CTNND2GT24 | NPRAPcatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)-HPRD,BioGRID11729199 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-WesternBioGRID12390249 
SSSCA1p27Sjogren syndrome/scleroderma autoantigen 1Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-13389951Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-1853423481Ahsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-218313319m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-33885911Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-34b357363m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-452981041Ahsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-485-5p208214m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-539107710841A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-5431541601Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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