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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NLGN2

Summary

GeneID

57555

Symbol

NLGN2

Synonyms

KIAA1366

Description

neuroligin 2

Locus tag

Gene type

protein-coding

Map location

17p13.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 3

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PMPCA

0.87

0.84

FARSA

0.87

0.81

STK25

0.86

0.82

VPS4A

0.86

0.82

DBNL

0.85

0.83

LDOC1

0.85

0.82

POLR2E

0.84

0.83

ARFIP2

0.84

0.79

PPP5C

0.84

0.82

TCF25

0.84

0.79

Top 10 negatively co-expressed genes

MT-CO2

-0.70

-0.60

AF347015.31

-0.69

-0.62

AF347015.8

-0.69

-0.62

AF347015.2

-0.69

-0.61

AF347015.33

-0.69

-0.61

MT-CYB

-0.68

-0.61

AF347015.26

-0.68

-0.63

AF347015.21

-0.68

-0.59

AF347015.27

-0.66

-0.62

AF347015.15

-0.66

-0.62

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0042043

neurexin binding

NAS

Synap (GO term level: 4)

10892652

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007416

synaptogenesis

NAS

Synap (GO term level: 6)

10892652

GO:0016337

cell-cell adhesion

NAS

10892652

GO:0045217

cell-cell junction maintenance

NAS

10892652

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0045211

postsynaptic membrane

NAS

Synap, Neurotransmitter (GO term level: 5)

10892652

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0016021

integral to membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	Two-hybrid	BioGRID	9278515
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	Two-hybrid	BioGRID	9278515
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Two-hybrid	BioGRID	9278515
INADL	Cipp \| FLJ26982 \| InaD-like \| PATJ	InaD-like (Drosophila)	-	HPRD	9647694
NRXN1	DKFZp313P2036 \| FLJ35941 \| Hs.22998 \| KIAA0578	neurexin 1	-	HPRD,BioGRID	8576240
NRXN2	FLJ40892 \| KIAA0921	neurexin 2	Reconstituted Complex	BioGRID	8576240
NRXN3	KIAA0743 \| MGC176711	neurexin 3	Reconstituted Complex	BioGRID	8576240

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CELL_ADHESION_MOLECULES_CAMS	134	93	All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP	35	32	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP	428	266	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK	1210	725	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED	536	296	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN	668	419	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	228	119	All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN	207	139	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP	489	314	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY	1725	838	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-182	1640	1646	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-182	1640	1646	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-223	1676	1682	1A	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-370	1493	1500	1A,m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-7	1669	1676	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-96	1066	1073	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	1066	1073	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.