Gene Page: PTPN6

Summary
GeneID  5777
Symbol  PTPN6
Synonyms  HCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1
Description  protein tyrosine phosphatase, non-receptor type 6
See related  HGNC:9658|MIM:176883|Ensembl:ENSG00000111679|HPRD:01475|
Locus tag  -
Gene type  protein-coding
Map location  12p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0286 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI10660620 
GO:0004725protein tyrosine phosphatase activityIEA-
GO:0004725protein tyrosine phosphatase activityTAS1732748 
GO:0016787hydrolase activityIEA-
GO:0016791phosphatase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS7781604 
GO:0006470protein amino acid dephosphorylationIEA-
GO:0006470protein amino acid dephosphorylationTAS1732748 
GO:0007165signal transductionTAS10506221 
GO:0008285negative regulation of cell proliferationNAS10497187 
GO:0006915apoptosisTAS10506221 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9774457 
GO:0005575cellular_componentND-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneTAS10506221 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-WesternBioGRID8692915 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster region-HPRD,BioGRID9211920 
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD,BioGRID11356834 
BTLABTLA1 | CD272 | FLJ16065 | MGC129743B and T lymphocyte associated-HPRD12796776 
C6orf25G6b | MGC142279 | MGC142281 | NG31chromosome 6 open reading frame 25-HPRD,BioGRID11544253 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID12176037 
caveolin-1 interacts with PTP-1C.BIND12176037 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID12176909 
CD22FLJ22814 | MGC130020 | SIGLEC-2 | SIGLEC2CD22 molecule-HPRD,BioGRID9890995 
CD300LFCD300f | CLM1 | IREM1 | IgSF13 | NKIRCD300 molecule-like family member f-HPRD14662855 |15184070 
|15549731 
CD33FLJ00391 | SIGLEC-3 | SIGLEC3 | p67CD33 molecule-HPRD,BioGRID10206955 
CD5LEU1 | T1CD5 molecule-HPRD,BioGRID10082557 
CD72CD72b | LYB2CD72 moleculeAffinity Capture-Western
Reconstituted Complex		BioGRID9590210 |11114375 
|12882840 
-HPRD9590210 |9740800 
CEACAM1BGP | BGP1 | BGPIcarcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)-HPRD9867848 
CLEC4ACLECSF6 | DCIR | DDB27 | HDCGC13P | LLIRC-type lectin domain family 4, member A-HPRD11178971 
CSF2RBCD131 | CDw131 | IL3RB | IL5RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)-HPRD,BioGRID8246974 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1-HPRD,BioGRID10835420 
CXCR4CD184 | D2S201E | FB22 | HM89 | HSY3RR | LAP3 | LCR1 | LESTR | NPY3R | NPYR | NPYRL | NPYY3R | WHIMchemokine (C-X-C motif) receptor 4-HPRD,BioGRID10506573 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD10585470 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9733788 
EPORMGC138358erythropoietin receptor-HPRD,BioGRID7889566 
FCGR2BCD32 | CD32B | FCG2 | FCGR2 | IGFR2Fc fragment of IgG, low affinity IIb, receptor (CD32)-HPRD7716523 
FCRL3FCRH3 | IFGP3 | IRTA3 | SPAP2Fc receptor-like 3Affinity Capture-Western
Reconstituted Complex		BioGRID12051764 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11895767 
GHRGHBPgrowth hormone receptor-HPRD9632636 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID11964172 
HOXA10HOX1 | HOX1.8 | HOX1H | MGC12859 | PLhomeobox A10-HPRD,BioGRID12145285 
IFNAR1AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRCinterferon (alpha, beta and omega) receptor 1-HPRD9029147 
-HPRD8524272 |9029147 
IL4RCD124 | IL4RAinterleukin 4 receptor-HPRD,BioGRID11714803 
IL6STCD130 | CDw130 | GP130 | GP130-RAPS | IL6R-betainterleukin 6 signal transducer (gp130, oncostatin M receptor)-HPRD,BioGRID10800945 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID7512963 
IRS4IRS-4 | PY160insulin receptor substrate 4-HPRD12774026 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)Biochemical ActivityBioGRID7629131 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID8943354 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID7684496 |9528781 
KLRC1CD159A | MGC13374 | MGC59791 | NKG2 | NKG2Akiller cell lectin-like receptor subfamily C, member 1-HPRD9485206 
LAIR1CD305 | LAIR-1leukocyte-associated immunoglobulin-like receptor 1-HPRD9285412 |10764762 
|11160222|11160222 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9285412 |10660620 
|10764762 |10903717 
|11160222 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD8114715 |11294838 
Biochemical Activity
in vitro
in vivo		BioGRID8114715 |10617656 
|11294838 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD,BioGRID8760799 |9765283 
LIFRCD118 | FLJ98106 | FLJ99923 | LIF-R | SJS2 | STWS | SWSleukemia inhibitory factor receptor alpha-HPRD,BioGRID10800945 
LILRB2CD85D | ILT4 | LILRA6 | LIR-2 | LIR2 | MIR-10 | MIR10leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2-HPRD,BioGRID9531263 |9842885 
LILRB4CD85K | HM18 | ILT3 | LILRB5 | LIR-5 | LIR5leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4-HPRD,BioGRID9151699 |9973385 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID10574931 
NOS1IHPS1 | NOS | nNOSnitric oxide synthase 1 (neuronal)-HPRD,BioGRID11511520 
PAG1CBP | FLJ37858 | MGC138364 | PAGphosphoprotein associated with glycosphingolipid microdomains 1-HPRD,BioGRID10790433 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID9774457 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Two-hybridBioGRID11160222 
-HPRD11337495 
PILRAFDF03paired immunoglobin-like type 2 receptor alpha-HPRD,BioGRID10660620 |10903717 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID11723252 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10521452 |10747947 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD9368621 |10228003 
ROS1MCF3 | ROS | c-ros-1c-ros oncogene 1 , receptor tyrosine kinase-HPRD,BioGRID11266449 
SIGLEC11-sialic acid binding Ig-like lectin 11-HPRD,BioGRID11986327 
SIGLEC12FLJ38600 | S2V | SIGLECL1 | SLG | Siglec-12 | Siglec-L1 | Siglec-XIIsialic acid binding Ig-like lectin 12-HPRD11328818 
SIRPABIT | CD172A | MFR | MYD-1 | P84 | PTPNS1 | SHPS-1 | SHPS1 | SIRP | SIRP-ALPHA-1 | SIRPalpha | SIRPalpha2signal-regulatory protein alpha-HPRD,BioGRID10660565 
-HPRD10660565 |14662855 
SLAMF6KALI | KALIb | Ly108 | MGC104953 | NTB-A | NTBA | SF2000SLAM family member 6-HPRD,BioGRID11489943 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Affinity Capture-WesternBioGRID8632004 
SSTR2-somatostatin receptor 2-HPRD,BioGRID9305905 |11920268 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD,BioGRID9211920 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseAffinity Capture-Western
Biochemical Activity		BioGRID10072516 |10747947 
-HPRD10072516 |11356834 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD11786908 
TREML1GLTL1825 | MGC119173 | PRO3438 | TLT-1 | TLT1 | dJ238O23.3triggering receptor expressed on myeloid cells-like 1-HPRD,BioGRID12393607 
TYK2JTK1tyrosine kinase 2-HPRD,BioGRID7629131 |8780698 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID8632004 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID8638162 |10458769 
 


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