Gene Page: MARK4

Summary
GeneID  57787
Symbol  MARK4
Synonyms  FLJ90097|KIAA1860|MARKL1|Nbla00650
Description  MAP/microtubule affinity-regulating kinase 4
See related  HGNC:13538|MIM:606495|Ensembl:ENSG00000007047|HPRD:09402|
Locus tag  -
Gene type  protein-coding
Map location  19q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BRMS1L0.840.86
FAM102B0.830.83
OXCT10.810.81
VAPB0.810.83
EPS150.810.81
USP120.800.80
MCFD20.800.80
SGTB0.800.80
CDC400.800.78
TRAPPC6B0.800.78
Top 10 negatively co-expressed genes
EFEMP2-0.39-0.46
NUDT8-0.38-0.46
NDUFA4L2-0.38-0.41
EIF4EBP3-0.38-0.42
AF347015.18-0.37-0.30
GATSL3-0.37-0.43
TMEM88-0.36-0.43
MICALL2-0.35-0.37
AP003068.3-0.35-0.34
SLC38A5-0.35-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0050321tau-protein kinase activityIDABrain (GO term level: 7)14594945 
GO:0050321tau-protein kinase activityISSBrain (GO term level: 7)-
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI14594945 |14676191 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS15009667 
GO:0004674protein serine/threonine kinase activityIDA15009667 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004674protein serine/threonine kinase activityISS-
GO:0004674protein serine/threonine kinase activityNAS11326310 
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008017microtubule bindingIDA14594945 
GO:0008017microtubule bindingISS-
GO:0043130ubiquitin bindingNAS14594945 
GO:0043015gamma-tubulin bindingIDA14594945 
GO:0043015gamma-tubulin bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIDAneurite (GO term level: 5)14594945 
GO:0007399nervous system developmentISSneurite (GO term level: 5)-
GO:0000082G1/S transition of mitotic cell cycleNAS12735302 
GO:0000086G2/M transition of mitotic cell cycleNAS11326310 
GO:0001578microtubule bundle formationIEP14594945 
GO:0001578microtubule bundle formationISS-
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationNAS11326310 
GO:0006468protein amino acid phosphorylationTAS14594945 
GO:0016055Wnt receptor signaling pathwayTAS11326310 
GO:0008284positive regulation of cell proliferationIDA12735302 
GO:0043068positive regulation of programmed cell deathNAS15009667 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionIDAneuron, axon, neurite, dendrite (GO term level: 5)14594945 
GO:0043005neuron projectionISSneuron, axon, neurite, dendrite (GO term level: 5)-
GO:0000930gamma-tubulin complexIDA14594945 
GO:0005813centrosomeIDA14594945 
GO:0005813centrosomeISS-
GO:0005815microtubule organizing centerIDA14594945 
GO:0005874microtubuleIDA14594945 
GO:0005737cytoplasmIDA11326310 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscleAffinity Capture-MSBioGRID14594945 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4Affinity Capture-MSBioGRID14594945 
MAP2DKFZp686I2148 | MAP2A | MAP2B | MAP2Cmicrotubule-associated protein 2-HPRD,BioGRID14594945 
MAP4DKFZp779A1753 | MGC8617microtubule-associated protein 4-HPRD,BioGRID14594945 
MAPTDDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAUmicrotubule-associated protein tau-HPRD,BioGRID14594945 
MYH10MGC134913 | MGC134914 | NMMHCBmyosin, heavy chain 10, non-muscleAffinity Capture-MSBioGRID14594945 
MYH9DFNA17 | EPSTS | FTNS | MGC104539 | MHA | NMHC-II-A | NMMHCAmyosin, heavy chain 9, non-muscleAffinity Capture-MSBioGRID14594945 
STK11LKB1 | PJSserine/threonine kinase 11LKB1 phosphorylates MARK4.BIND14676191 
TUBA1AB-ALPHA-1 | FLJ25113 | LIS3 | TUBA3tubulin, alpha 1aAffinity Capture-MSBioGRID14594945 
TUBBM40 | MGC117247 | MGC16435 | OK/SW-cl.56 | TUBB1 | TUBB5tubulin, betaAffinity Capture-MSBioGRID14594945 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2A-HPRD14594945 
TUBG1TUBG | TUBGCP1tubulin, gamma 1Affinity Capture-MS
Affinity Capture-Western		BioGRID14594945 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5 9459All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d759765m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-21495101m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-242692761A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-493-5p7657711Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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