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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PTPRA

Summary

GeneID

5786

Symbol

PTPRA

Synonyms

Description

protein tyrosine phosphatase, receptor type, A

Locus tag

RP4-534B8.1

Gene type

protein-coding

Map location

20p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0261

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PIP5K1C

0.90

0.89

ABR

0.89

0.90

UNC13A

0.89

RHOBTB2

0.89

CLSTN1

0.87

0.88

PITPNM2

0.87

0.83

CHD5

0.87

0.85

TLN2

0.87

0.86

GARNL4

0.87

0.85

RIMBP2

0.86

0.84

Top 10 negatively co-expressed genes

AF347015.21

-0.49

-0.50

C1orf54

-0.48

-0.57

GNG11

-0.48

-0.56

C1orf61

-0.45

-0.52

AP002478.3

-0.44

-0.48

AF347015.31

-0.43

-0.47

RPS27L

-0.43

-0.45

SYCP3

-0.42

-0.50

CLEC2B

-0.42

-0.48

SAT1

-0.42

-0.49

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

TAS

2169617

GO:0004872

receptor activity

IEA

GO:0016787

hydrolase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006470

protein amino acid dephosphorylation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0005887

integral to plasma membrane

TAS

2169617

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	9535845
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	An unspecified isoform of GRB2 interacts with PTPRA.	BIND	8670803
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	7518772 \|8670803 \|11923305
KCNA2	HBK5 \| HK4 \| HUKIV \| KV1.2 \| MGC50217 \| MK2 \| NGK1 \| RBK2	potassium voltage-gated channel, shaker-related subfamily, member 2	Affinity Capture-Western Reconstituted Complex	BioGRID	9878055
PTPRA	HEPTP \| HLPR \| HPTPA \| HPTPalpha \| LRP \| PTPA \| PTPRL2 \| R-PTP-alpha \| RPTPA	protein tyrosine phosphatase, receptor type, A	RPTP-alpha forms a homodimer.	BIND	11401727
PTPRD	HPTP \| HPTP-DELTA \| HPTPD \| MGC119750 \| MGC119751 \| MGC119752 \| MGC119753 \| PTPD \| R-PTP-DELTA	protein tyrosine phosphatase, receptor type, D	-	HPRD	10777529
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	protein tyrosine phosphatase, receptor type, F	-	HPRD	10777529
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western	BioGRID	11923305

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
BIOCARTA_SRCRPTP_PATHWAY	11	9	All SZGR genes in this pathway
ST_WNT_BETA_CATENIN_PATHWAY	34	28	All SZGR genes in this pathway
PID_INSULIN_PATHWAY	45	32	All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY	33	24	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2	127	92	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_UP	38	25	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002	429	260	All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA	447	277	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN	366	257	All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP	36	24	All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN	457	302	All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP	605	377	All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP	104	67	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL	162	122	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	311	317	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-146	352	359	1A,m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	352	359	1A,m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-218	344	351	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-495	59	65	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	151	157	1A	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.