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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PEX5

Summary

GeneID

5830

Symbol

PEX5

Synonyms

FLJ50634|FLJ50721|FLJ51948|PTS1-BP|PTS1R|PXR1

Description

peroxisomal biogenesis factor 5

Locus tag

Gene type

protein-coding

Map location

12p13.31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ATAD1

0.93

0.91

SLC30A9

0.92

0.91

RAB18

0.92

CUL2

0.92

0.89

STX12

0.92

0.91

FAM49B

0.92

0.90

USP33

0.92

0.90

C10orf88

0.91

0.90

PPP2CA

0.91

0.89

CCDC132

0.91

0.89

Top 10 negatively co-expressed genes

MT-CO2

-0.74

-0.68

AF347015.33

-0.72

-0.66

AF347015.8

-0.71

-0.67

MT-CYB

-0.71

-0.66

FXYD1

-0.71

-0.68

AF347015.2

-0.71

-0.65

AF347015.26

-0.71

-0.66

HIGD1B

-0.69

-0.64

AF347015.31

-0.69

-0.65

AF347015.21

-0.69

-0.60

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

9653144 |10837480

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001764

neuron migration

IEA

neuron (GO term level: 8)

GO:0021895

cerebral cortex neuron differentiation

IEA

neuron, Brain (GO term level: 9)

GO:0000038

very-long-chain fatty acid metabolic process

IEA

GO:0007006

mitochondrial membrane organization

IEA

GO:0048468

cell development

IEA

GO:0007031

peroxisome organization

IEA

GO:0007029

endoplasmic reticulum organization

IEA

GO:0006635

fatty acid beta-oxidation

IEA

GO:0015031

protein transport

IEA

GO:0040018

positive regulation of multicellular organism growth

IEA

GO:0021795

cerebral cortex cell migration

IEA

GO:0044255

cellular lipid metabolic process

IEA

GO:0050905

neuromuscular process

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

GO:0005777

peroxisome

IEA

GO:0005778

peroxisomal membrane

IEA

GO:0016020

membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATM	AT1 \| ATA \| ATC \| ATD \| ATDC \| ATE \| DKFZp781A0353 \| MGC74674 \| TEL1 \| TELO1	ataxia telangiectasia mutated	-	HPRD,BioGRID	10567403
CAT	MGC138422 \| MGC138424	catalase	Two-hybrid	BioGRID	10567403
DDO	DASOX \| DDO-1 \| DDO-2 \| FLJ45203	D-aspartate oxidase	-	HPRD,BioGRID	9820813
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	11415446
PDZK1	CAP70 \| CLAMP \| NHERF3 \| PDZD1	PDZ domain containing 1	Two-hybrid	BioGRID	16189514
PEX10	MGC1998 \| NALD \| RNF69	peroxisomal biogenesis factor 10	-	HPRD,BioGRID	10837480
PEX12	PAF-3	peroxisomal biogenesis factor 12	PEX12 interacts with PEX5.	BIND	12096124
PEX12	PAF-3	peroxisomal biogenesis factor 12	-	HPRD,BioGRID	10562279 \|10837480
PEX13	NALD \| ZWS	peroxisomal biogenesis factor 13	-	HPRD,BioGRID	8858165 \|11865044
PEX14	MGC12767 \| NAPP2 \| Pex14p \| dJ734G22.2	peroxisomal biogenesis factor 14	PEX14 interacts with PEX5.	BIND	12096124
			Reconstituted Complex Two-hybrid	BioGRID	10212238 \|10837480 \|11865044
			-	HPRD	10212238 \|11865044
PEX7	PTS2R \| RCDP1 \| RD	peroxisomal biogenesis factor 7	-	HPRD,BioGRID	11546814 \|11865044
PXMP3	PAF-1 \| PAF1 \| PEX2 \| PMP3 \| PMP35 \| RNF72	peroxisomal membrane protein 3, 35kDa	-	HPRD	10837480
SIRT3	SIR2L3	sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)	Two-hybrid	BioGRID	16189514
SNUPN	KPNBL \| RNUT1 \| Snurportin1	snurportin 1	Two-hybrid	BioGRID	16169070

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_PEROXISOME	78	47	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN	526	357	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN	241	146	All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_DN	86	47	All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP	133	78	All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5	147	89	All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK	101	73	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
ZHAN_V2_LATE_DIFFERENTIATION_GENES	45	34	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP	43	33	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN	911	527	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN	1011	592	All SZGR genes in this pathway
YOSHIOKA_LIVER_CANCER_EARLY_RECURRENCE_UP	40	23	All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP	84	51	All SZGR genes in this pathway
TERAO_AOX4_TARGETS_HG_UP	28	20	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D	882	506	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_WITH_H4K20ME1_MARK	145	82	All SZGR genes in this pathway
ALFANO_MYC_TARGETS	239	156	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-141/200a	919	926	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	919	926	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	272	278	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-29	269	275	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-31	892	899	1A,m8	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-361	330	336	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.