Gene Page: ROBO2

Summary
GeneID  6092
Symbol  ROBO2
Synonyms  KIAA1568|SAX3
Description  roundabout, axon guidance receptor, homolog 2 (Drosophila)
See related  HGNC:10250|MIM:602431|Ensembl:ENSG00000185008|
Locus tag  -
Gene type  protein-coding
Map location  3p12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.04047 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04359 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TUT10.990.95
EIF3H0.980.93
IGBP10.970.94
EIF3L0.970.95
NACA0.960.95
AC005393.10.960.91
BTF30.960.97
RPS80.960.88
VPS720.960.93
RPL50.960.94
Top 10 negatively co-expressed genes
HLA-F-0.70-0.76
AIFM3-0.68-0.75
FBXO2-0.68-0.66
C5orf53-0.67-0.67
LDHD-0.66-0.67
TINAGL1-0.65-0.77
AF347015.27-0.65-0.81
ALDOC-0.65-0.68
CLU-0.65-0.68
PTH1R-0.65-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008046axon guidance receptor activityNASaxon (GO term level: 6)9458045 
GO:0042802identical protein bindingIDA12504588 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEPBrain (GO term level: 7)10197527 
GO:0050772positive regulation of axonogenesisIDAaxon, neurogenesis (GO term level: 14)12504588 
GO:0001657ureteric bud developmentIMP15130495 
GO:0007155cell adhesionIEA-
GO:0007156homophilic cell adhesionIDA12504588 
GO:0006935chemotaxisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA12504588 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPE-carboxypeptidase ETwo-hybridBioGRID16169070 
SLIT2FLJ14420 | SLIL3 | Slit-2slit homolog 2 (Drosophila)-HPRD,BioGRID10102268 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR 3026All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_DN 3520All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
DING_LUNG_CANCER_BY_MUTATION_RATE 2018All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K4ME3_AND_H3K27ME3 3834All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3 12683All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_DN 11573All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1015135201A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-130/301428434m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1445145201Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-148/152429435m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1532963031A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-181901961Ahsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-181493499m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1859349401Ahsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-19427433m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-2184534601A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-234955021A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/3677682m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-3234955011Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-331151211Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-378207213m8hsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-4482973031Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4961211271Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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