Gene Page: ROCK1

Summary
GeneID  6093
Symbol  ROCK1
Synonyms  MGC131603|MGC43611|P160ROCK|PRO0435
Description  Rho-associated, coiled-coil containing protein kinase 1
See related  HGNC:10251|MIM:601702|Ensembl:ENSG00000067900|HPRD:03414|
Locus tag  -
Gene type  protein-coding
Map location  18q11.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0021 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RPS80.970.94
BTF30.970.94
RPL40.960.94
RPS60.960.95
NACA0.950.94
TUT10.950.91
RPL10A0.950.97
IGBP10.940.89
RPL6P100.940.93
RPS3P30.940.93
Top 10 negatively co-expressed genes
FBXO2-0.67-0.71
HLA-F-0.67-0.74
ATP10A-0.67-0.79
AIFM3-0.65-0.72
ARHGAP22-0.64-0.71
APOL1-0.64-0.79
SLC6A12-0.63-0.79
TINAGL1-0.63-0.77
APOL3-0.63-0.79
LDHD-0.63-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityTAS8798490 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0042802identical protein bindingIPI16249185 
GO:0019992diacylglycerol bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043524negative regulation of neuron apoptosisIEAneuron (GO term level: 9)-
GO:0000910cytokinesisIEA-
GO:0022614membrane to membrane dockingIDA12082081 
GO:0006468protein amino acid phosphorylationTAS10436159 
GO:0007266Rho protein signal transductionTAS8798490 
GO:0007242intracellular signaling cascadeIEA-
GO:0006915apoptosisIEA-
GO:0030036actin cytoskeleton organizationTAS10436159 
GO:0050901leukocyte tethering or rollingIDA12082081 
GO:0050900leukocyte migrationIDA12082081 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005829cytosolEXP16983089 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC25ACDC25A2cell division cycle 25 homolog A (S. pombe)-HPRD,BioGRID14657354 
CFL1CFLcofilin 1 (non-muscle)Affinity Capture-WesternBioGRID10436159 
GAB1-GRB2-associated binding protein 1Co-crystal StructureBioGRID12748184 
LIMK1LIMKLIM domain kinase 1-HPRD10436159 
LIMK2-LIM domain kinase 2Biochemical ActivityBioGRID10436159 
MBPMGC99675myelin basic proteinROCK1 (ROCK) interacts with and phosphorylates MBP.BIND15797222 
PFN2D3S1319E | PFLprofilin 2-HPRD,BioGRID14517206 
PTEN10q23del | BZS | MGC11227 | MHAM | MMAC1 | PTEN1 | TEP1phosphatase and tensin homologPTEN interacts with Rock1.BIND15793569 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member A-HPRD,BioGRID8798490 
RND3ARHE | Rho8 | RhoE | memBRho family GTPase 3-HPRD,BioGRID12773565 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
BIOCARTA_ECM_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_MYOSIN_PATHWAY 3122All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 3525All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY 3226All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_THROMBIN_PAR4_PATHWAY 1511All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 3222All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 2721All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_IMMORTALIZED_DN 3126All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BURTON_ADIPOGENESIS_12 3618All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_DN 2314All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_1HR_DN 108All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.19319381A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5069309371A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1356997061A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1395385451A,m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-145135713631Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152141414201Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1506536591Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-153684690m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-182694700m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-19014381444m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-199135613621Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-217133013361Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-32313351341m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-332182241Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-335472478m8hsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-34/4499569621Ahsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-493-5p7457511Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4946316381A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-4968808861Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-539153515411Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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