Gene Page: S100A1

Summary
GeneID  6271
Symbol  S100A1
Synonyms  S100|S100-alpha|S100A
Description  S100 calcium binding protein A1
See related  HGNC:10486|MIM:176940|Ensembl:ENSG00000160678|HPRD:01489|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SPTBN20.900.92
AP3D10.890.89
NCLN0.890.90
AGAP30.890.88
KIAA06640.890.89
MARK20.890.89
MGAT30.890.91
ADRBK10.880.88
BRSK20.880.89
SAPS20.880.89
Top 10 negatively co-expressed genes
AF347015.21-0.74-0.71
GNG11-0.69-0.68
AF347015.31-0.68-0.63
MT-CO2-0.68-0.63
C1orf54-0.68-0.71
NOSTRIN-0.66-0.61
AF347015.8-0.65-0.61
HIGD1B-0.64-0.60
AP002478.3-0.64-0.62
AF347015.33-0.64-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0048155S100 alpha bindingIPIastrocyte (GO term level: 4)10913138 
GO:0048154S100 beta bindingIPIastrocyte (GO term level: 4)10913138 
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingTAS1998503 
GO:0008270zinc ion bindingIEA-
GO:0051117ATPase bindingIPI12804600 
GO:0042802identical protein bindingIEA-
GO:0042803protein homodimerization activityIDA10913138 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007242intracellular signaling cascadeNAS12804600 
GO:0008016regulation of heart contractionNAS12804600 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0016529sarcoplasmic reticulumIDA12804600 
GO:0016529sarcoplasmic reticulumIEA-
GO:0043231intracellular membrane-bounded organelleIDA18029348 
GO:0043234protein complexNAS14638689 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGERMGC22357 | RAGEadvanced glycosylation end product-specific receptor-HPRD11007787 
ANXA6ANX6 | CBP68annexin A6-HPRD,BioGRID9883272 
ATP2A2ATP2B | DAR | DD | DKFZp686P0211 | FLJ20293 | FLJ38063 | MGC45367 | SERCA2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2-HPRD,BioGRID12804600 
CACYBPGIG5 | MGC87971 | PNAS-107 | RP1-102G20.6 | S100A6BP | SIPcalcyclin binding protein-HPRD12042313 
DESCMD1I | CSM1 | CSM2 | FLJ12025 | FLJ39719 | FLJ41013 | FLJ41793desmin-HPRD,BioGRID8641565 
GFAPFLJ45472glial fibrillary acidic protein-HPRD10510252 
GJA1CX43 | DFNB38 | GJAL | ODDDgap junction protein, alpha 1, 43kDa-HPRD,BioGRID12804600 
NIF3L1ALS2CR1 | CALS-7 | MDS015NIF3 NGG1 interacting factor 3-like 1 (S. pombe)Two-hybridBioGRID16189514 
PGM1-phosphoglucomutase 1Affinity Capture-Western
Far Western		BioGRID8894274 
PLB1PLBphospholipase B1Affinity Capture-WesternBioGRID12804600 
PYGM-phosphorylase, glycogen, muscleAffinity Capture-WesternBioGRID12804600 
RYR1CCO | MHS | MHS1 | RYDR | RYR | SKRRryanodine receptor 1 (skeletal)-HPRD,BioGRID9298970 
S100A1S100 | S100-alpha | S100AS100 calcium binding protein A1Co-purification
Two-hybrid		BioGRID9803314 |16189514 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4-HPRD,BioGRID10753920 
-HPRD9926943 |10753920 
|10869553 |15608682 
S100A4 interacts with S100A1BIND10753920 
S100BNEF | S100 | S100betaS100 calcium binding protein BAffinity Capture-Western
Two-hybrid		BioGRID9925766 |10913138 
|16189514 
S100A1 interacts with S100B.BIND10913138 
S100PMIG9S100 calcium binding protein PTwo-hybridBioGRID16189514 
 


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