Gene Page

Gene Page: SCN1A

Summary

GeneID

6323

Symbol

SCN1A

Synonyms

FEB3|GEFSP2|HBSCI|NAC1|Nav1.1|SCN1|SMEI

Description

sodium channel, voltage-gated, type I, alpha subunit

Locus tag

Gene type

protein-coding

Map location

2q24.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.02395

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005244

voltage-gated ion channel activity

IEA

GO:0005248

voltage-gated sodium channel activity

NAS

10742094

GO:0031402

sodium ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006814

sodium ion transport

NAS

10742094

GO:0006811

ion transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001518

voltage-gated sodium channel complex

IEA

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

NAS

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
SNTA1	SNT1 \| TACIP1 \| dJ1187J4.5	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	Affinity Capture-Western Protein-peptide	BioGRID	9412493

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1426	1432	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-132/212	101	107	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	101	107	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-137	1271	1278	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-5p	882	888	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-144	1425	1432	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-149	1343	1349	1A	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-17-5p/20/93.mr/106/519.d	326	332	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	92	98	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-200bc/429	1036	1042	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-214	233	239	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-218	1031	1037	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-223	97	103	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-27	44	50	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	44	50	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	34	41	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-34/449	365	371	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-363	751	757	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-363	751	757	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-452	1013	1019	1A	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-452	1013	1019	1A	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-493-5p	1463	1469	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-500	749	756	1A,m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-96	92	98	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.