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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SCN2A

Summary

GeneID

6326

Symbol

SCN2A

Synonyms

HBA|HBSCI|HBSCII|NAC2|Na(v)1.2|Nav1.2|SCN2A1|SCN2A2

Description

sodium channel, voltage-gated, type II, alpha subunit

Locus tag

Gene type

protein-coding

Map location

2q23-q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.02395

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005244

voltage-gated ion channel activity

IEA

GO:0005248

voltage-gated sodium channel activity

TAS

1325650

GO:0031402

sodium ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006814

sodium ion transport

TAS

1325650

GO:0006811

ion transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001518

voltage-gated sodium channel complex

IEA

GO:0016020

membrane

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANK3	ANKYRIN-G \| FLJ45464	ankyrin 3, node of Ranvier (ankyrin G)	Affinity Capture-Western	BioGRID	14761957
SCN4B	-	sodium channel, voltage-gated, type IV, beta	-	HPRD	12930796

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS	86	62	All SZGR genes in this pathway
REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	23	19	All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP	85	54	All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP	182	110	All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP	194	122	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN	281	186	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN	357	212	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
KONDO_EZH2_TARGETS	245	148	All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP	149	85	All SZGR genes in this pathway
LE_NEURONAL_DIFFERENTIATION_UP	18	13	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1735	1742	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	560	567	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	560	567	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124.1	1812	1818	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1812	1818	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1812	1818	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-135	1326	1333	1A,m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1326	1333	1A,m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-142-5p	2096	2102	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d	1659	1665	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	93	99	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-200bc/429	1020	1026	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-214	234	240	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-217	1018	1024	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-218	1152	1158	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-30-5p	439	445	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
				hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	699	705	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-330	1091	1097	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-335	1042	1048	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-34/449	368	374	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-496	310	316	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	310	316	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-542-3p	1251	1257	m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-96	93	99	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.