Gene Page: SCNN1G

Summary
GeneID  6340
Symbol  SCNN1G
Synonyms  ENaCg|ENaCgamma|PHA1|SCNEG
Description  sodium channel, nonvoltage-gated 1, gamma
See related  HGNC:10602|MIM:600761|Ensembl:ENSG00000166828|HPRD:02862|
Locus tag  -
Gene type  protein-coding
Map location  16p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FMNL10.920.89
RASGRF10.890.83
CTSB0.890.85
PTPRN0.890.85
GRIN10.880.82
TMEM38A0.880.93
CNNM10.880.76
ADAMTS80.880.89
PRRT30.880.89
TMEM132D0.870.81
Top 10 negatively co-expressed genes
TUBB2B-0.47-0.58
KIAA1949-0.47-0.47
TRAF4-0.46-0.60
RPL23A-0.46-0.63
RBMX2-0.46-0.66
FADS2-0.46-0.49
CARHSP1-0.46-0.63
BCL7C-0.45-0.60
DYNLT1-0.45-0.65
GPR125-0.45-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11244092 
GO:0005216ion channel activityIEA-
GO:0015280amiloride-sensitive sodium channel activityTAS8640238 
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007588excretionTAS8640238 
GO:0006814sodium ion transportTAS8521520 
GO:0006811ion transportIEA-
GO:0050896response to stimulusIEA-
GO:0050909sensory perception of tasteIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8640238 
GO:0016324apical plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NEDD4KIAA0093 | MGC176705 | NEDD4-1 | RPF1neural precursor cell expressed, developmentally down-regulated 4-HPRD,BioGRID10642508 
-HPRD10212229 |10642508 
|11359767|10642508 
NEDD4LFLJ33870 | KIAA0439 | NEDD4-2 | RSP5 | hNedd4-2neural precursor cell expressed, developmentally down-regulated 4-like-HPRD,BioGRID11244092 
SCNN1BENaCb | ENaCbeta | SCNEBsodium channel, nonvoltage-gated 1, beta-HPRD8986818 
SCNN1DENaCd | ENaCdelta | MGC149710 | MGC149711 | SCNED | dNaChsodium channel, nonvoltage-gated 1, delta-HPRD7499195 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD,BioGRID14996668 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2-HPRD,BioGRID12167593 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TASTE_TRANSDUCTION 5228All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
BALLIF_DEVELOPMENTAL_DISABILITY_P16_P12_DELETION 138All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K27ME3 7959All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway


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