Gene Page: SFRS6

Summary
GeneID  6431
Symbol  SFRS6
Synonyms  B52|FLJ08061|MGC5045|SRP55
Description  splicing factor, arginine/serine-rich 6
See related  HGNC:10788|MIM:601944|Ensembl:ENSG00000124193|HPRD:09054|
Locus tag  -
Gene type  protein-coding
Map location  20q12-q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.642 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0008380RNA splicingIEA-
GO:0006376mRNA splice site selectionTAS7556075 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CLK1CLK | CLK/STY | STYCDC-like kinase 1-HPRD12549978 
PPARGC1ALEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1peroxisome proliferator-activated receptor gamma, coactivator 1 alphaAffinity Capture-WesternBioGRID10983978 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainTwo-hybridBioGRID16189514 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD10757789 |14559993 
SFRS4SRP75splicing factor, arginine/serine-rich 4Two-hybridBioGRID16189514 
SRPK1SFRSK1SFRS protein kinase 1-HPRD8208298 |10340541 
SRPK2FLJ36101 | SFRSK2SFRS protein kinase 2Biochemical ActivityBioGRID9472028 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPLICEOSOME 12872All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 5434All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_MRNA_SPLICING 11158All SZGR genes in this pathway
REACTOME_MRNA_SPLICING_MINOR_PATHWAY 4519All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_MRNA_3_END_PROCESSING 3518All SZGR genes in this pathway
REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 4422All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_UP 2918All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_DN 3319All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_UP 4429All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_1 5133All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
UEDA_CENTRAL_CLOCK 8862All SZGR genes in this pathway
ZUCCHI_METASTASIS_UP 4324All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
MODY_HIPPOCAMPUS_PRENATAL 4233All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
BILD_CTNNB1_ONCOGENIC_SIGNATURE 8252All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
YEGNASUBRAMANIAN_PROSTATE_CANCER 12860All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UP 5132All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN 10367All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP 12170All SZGR genes in this pathway
AZARE_STAT3_TARGETS 2412All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1495501m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5064955011Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-125/351191419201Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-1376016071Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1385986041Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-14619011907m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-1915221A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-192/215507513m8hsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-918961902m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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