Gene Page: SLC1A1

Summary
GeneID  6505
Symbol  SLC1A1
Synonyms  EAAC1|EAAT3
Description  solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
See related  HGNC:10939|MIM:133550|Ensembl:ENSG00000106688|HPRD:00597|
Locus tag  RP11-6J24.1
Gene type  protein-coding
Map location  9p24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ATRN0.910.93
LARP4B0.890.90
ABHD20.890.90
MGAT50.890.90
CEP680.880.89
ATP9A0.880.90
KIAA14320.880.90
MTOR0.880.90
HDAC40.870.89
SRGAP30.870.89
Top 10 negatively co-expressed genes
C1orf54-0.63-0.71
AF347015.21-0.62-0.68
FXYD1-0.62-0.61
MT-CO2-0.60-0.64
AF347015.31-0.60-0.63
HIGD1B-0.59-0.62
SAT1-0.59-0.63
S100A13-0.59-0.63
AC021016.1-0.57-0.58
VAMP5-0.57-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0015501glutamate:sodium symporter activityIEAglutamate (GO term level: 11)-
GO:0015293symporter activityIEA-
GO:0017153sodium:dicarboxylate symporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)7521911 
GO:0015813L-glutamate transportTASglutamate (GO term level: 9)7521911 
GO:0006835dicarboxylic acid transportIEA-
GO:0006810transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS7521911 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS7521911 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARL6IP5DERP11 | GTRAP3-18 | HSPC127 | JWA | PRAF3 | addicsin | hp22 | jmxADP-ribosylation-like factor 6 interacting protein 5-HPRD,BioGRID11242046 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID12843260 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES 9465All SZGR genes in this pathway
REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS 4936All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_DN 3924All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_UP 2315All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_UP 11866All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
EHRLICH_ICF_SYNDROM_DN 1513All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_LUNG_DN 3722All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 7645All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1016066131A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-141/200a638644m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-1446076131Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-182152515311Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-237297361A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-267547611A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-3237297351Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3744414471Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-5393223281Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-9152715331Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96152415311A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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