Gene Page: RTN4R

Summary
GeneID  65078
Symbol  RTN4R
Synonyms  NGR|NOGOR
Description  reticulon 4 receptor
See related  HGNC:18601|MIM:605566|Ensembl:ENSG00000040608|HPRD:16123|
Locus tag  -
Gene type  protein-coding
Map location  22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityNAS11201742 
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisNASneuron, axon, neurite (GO term level: 12)11201742 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005783endoplasmic reticulumIDA11256614 
GO:0005886plasma membraneIEA-
GO:0031225anchored to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
LINGO1FLJ14594 | LERN1 | LRRN6A | MGC17422 | UNQ201leucine rich repeat and Ig domain containing 1LINGO-1 interacts with NgR1.BIND14966521 
MAGGMA | S-MAG | SIGLEC-4A | SIGLEC4Amyelin associated glycoprotein-HPRD12089450 |12160746 
NGFRCD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTRnerve growth factor receptor (TNFR superfamily, member 16)p75 interacts with NgR. This interaction was modeled on a demonstrated interaction between p75 and NgR both from an unspecified species.BIND15953414 
p75 interacts with NgR. This interaction was modelled on a demonstrated interaction between rat p75 and human NgR.BIND15694321 
-HPRD12422217 
p75 interacts with NgR1. This interaction was modeled on a demonstrated interaction between p75 from rat and NgR1 from human.BIND14966521 
OMGOMGPoligodendrocyte myelin glycoproteinReconstituted ComplexBioGRID12068310 
RTKN-rhotekinRhotekin interacts with NgR. This interaction was modelled on a demonstrated interaction between Rhotekin from an unspecified species and human NgR.BIND15694321 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4-HPRD11201742 
Nogo-66 interacts with NgR.BIND15694321 
RTN4IP1MGC12934 | NIMPreticulon 4 interacting protein 1-HPRD12160746 
TNFRSF19TAJ | TAJ-alpha | TRADE | TROYtumor necrosis factor receptor superfamily, member 19TROY interacts with NgR. This interaction was modelled on a demonstrated interaction between mouse TROY and human NgR.BIND15694321 
TROY interacts with NgR.BIND15694322 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM6 4632All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_DN 2019All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
NIELSEN_SYNOVIAL_SARCOMA_UP 1814All SZGR genes in this pathway


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