Gene Page: SLC22A4

Summary
GeneID  6583
Symbol  SLC22A4
Synonyms  MGC34546|MGC40524|OCTN1
Description  solute carrier family 22 (organic cation/ergothioneine transporter), member 4
See related  HGNC:10968|MIM:604190|Ensembl:ENSG00000197208|HPRD:09171|
Locus tag  -
Gene type  protein-coding
Map location  5q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RDH120.790.73
CPNE90.780.78
MEI10.770.61
TUBA80.760.68
GNG130.760.46
VWC20.750.62
AC010087.30.740.80
AL360181.50.740.84
TTC39A0.730.61
CLMN0.730.73
Top 10 negatively co-expressed genes
KIAA1949-0.48-0.69
TUBB2B-0.48-0.72
ZNF551-0.47-0.70
C19orf57-0.47-0.61
PCDHB18-0.46-0.67
ZNF642-0.46-0.65
CCNG2-0.46-0.64
AC004017.1-0.46-0.69
CD24-0.46-0.62
PLEKHO1-0.46-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingTAS9426230 
GO:0005524ATP bindingIEA-
GO:0005215transporter activityIEA-
GO:0008513secondary active organic cation transmembrane transporter activityTAS9426230 
GO:0015293symporter activityIEA-
GO:0015226carnitine transporter activityIDA16729965 
GO:0015075ion transmembrane transporter activityIEA-
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009437carnitine metabolic processIEA-
GO:0007589body fluid secretionTAS9426230 
GO:0006814sodium ion transportIEA-
GO:0006811ion transportIEA-
GO:0006641triacylglycerol metabolic processIEA-
GO:0015697quaternary ammonium group transportIEA-
GO:0015879carnitine transportIDA16729965 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIDA16729965 
GO:0005886plasma membraneTAS9426230 
GO:0005887integral to plasma membraneTAS9426230 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PDZK1CAP70 | CLAMP | NHERF3 | PDZD1PDZ domain containing 1Reconstituted Complex
Two-hybrid		BioGRID14531806 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS 8954All SZGR genes in this pathway
REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT 139All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN 349157All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
AMUNDSON_GAMMA_RADIATION_RESISTANCE 2014All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN 159105All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP 6543All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway


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