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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SMARCC2

Summary

GeneID

6601

Symbol

SMARCC2

Synonyms

BAF170|CRACC2|Rsc8

Description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Locus tag

Gene type

protein-coding

Map location

12q13-q14

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0178

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SSPN

0.84

PDLIM5

0.84

0.87

AQP4

0.81

0.77

TIMP3

0.81

0.83

MTM1

0.80

0.79

EDNRB

0.79

0.69

FIBIN

0.77

MYOM1

0.76

0.79

TMEM47

0.76

0.78

SPATA6

0.74

Top 10 negatively co-expressed genes

NR2C2AP

-0.40

-0.48

PLEKHO1

-0.39

-0.44

COMMD3

-0.38

-0.49

SLA

-0.37

-0.25

IER5L

-0.37

-0.33

MPPED1

-0.37

-0.32

ISLR2

-0.37

-0.27

AC011491.1

-0.37

-0.43

AC132872.1

-0.36

-0.50

SNHG12

-0.36

-0.53

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

IEA

GO:0003682

chromatin binding

IEA

GO:0003713

transcription coactivator activity

TAS

8804307

GO:0008022

protein C-terminus binding

IPI

12917342

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006333

chromatin assembly or disassembly

IEA

GO:0006357

regulation of transcription from RNA polymerase II promoter

TAS

8804307

GO:0006350

transcription

IEA

GO:0006338

chromatin remodeling

IDA

10078207 |11018012

GO:0045892

negative regulation of transcription, DNA-dependent

IDA

12192000

GO:0045893

positive regulation of transcription, DNA-dependent

IDA

11018012

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000785

chromatin

IEA

GO:0005622

intracellular

IEA

GO:0005634

nucleus

IEA

GO:0005654

nucleoplasm

TAS

8804307

GO:0017053

transcriptional repressor complex

IPI

12192000

GO:0016514

SWI/SNF complex

IDA

10078207

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	Affinity Capture-Western	BioGRID	9845365
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	Two-hybrid	BioGRID	16169070
BAZ1B	WBSCR10 \| WBSCR9 \| WSTF	bromodomain adjacent to zinc finger domain, 1B	-	HPRD,BioGRID	12837248
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Co-purification	BioGRID	10943845
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	Co-fractionation	BioGRID	9710619
GATA1	ERYF1 \| GF-1 \| GF1 \| NFE1	GATA binding protein 1 (globin transcription factor 1)	Reconstituted Complex	BioGRID	11018012
GRM2	GLUR2 \| GPRC1B \| MGLUR2 \| mGlu2	glutamate receptor, metabotropic 2	BAF170 interacts with mGluR2 promoter.	BIND	15035981
HSP90B1	ECGP \| GP96 \| GRP94 \| TRA1	heat shock protein 90kDa beta (Grp94), member 1	Affinity Capture-Western	BioGRID	11726552
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	Affinity Capture-MS	BioGRID	11784859
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	Two-hybrid	BioGRID	16169070
KLF1	EKLF	Kruppel-like factor 1 (erythroid)	Reconstituted Complex	BioGRID	11018012
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	-	HPRD	14743216
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	Co-purification	BioGRID	11013263
PEX14	MGC12767 \| NAPP2 \| Pex14p \| dJ734G22.2	peroxisomal biogenesis factor 14	Two-hybrid	BioGRID	16169070
PHYHIP	DYRK1AP3 \| KIAA0273 \| PAHX-AP \| PAHXAP1	phytanoyl-CoA 2-hydroxylase interacting protein	Two-hybrid	BioGRID	16169070
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	-	HPRD	9710619
POLR2C	RPB3 \| RPB31 \| hRPB33 \| hsRPB3	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	Two-hybrid	BioGRID	16169070
RELB	I-REL \| IREL	v-rel reticuloendotheliosis viral oncogene homolog B	-	HPRD,BioGRID	14743216
SMARCA2	BAF190 \| BRM \| FLJ36757 \| MGC74511 \| SNF2 \| SNF2L2 \| SNF2LA \| SWI2 \| Sth1p \| hBRM \| hSNF2a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Co-purification	BioGRID	8895581
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Affinity Capture-Western Co-purification	BioGRID	8895581 \|9845365 \|11726552
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Co-purification	BioGRID	8895581
SMARCD1	BAF60A \| CRACD1 \| Rsc6p	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	Affinity Capture-Western	BioGRID	12917342
SMARCE1	BAF57	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	Affinity Capture-Western	BioGRID	9845365
SP1	-	Sp1 transcription factor	Reconstituted Complex	BioGRID	11018012
SRGAP3	ARHGAP14 \| KIAA0411 \| MEGAP \| SRGAP2 \| WRP	SLIT-ROBO Rho GTPase activating protein 3	-	HPRD	12368262
STAT2	ISGF-3 \| MGC59816 \| P113 \| STAT113	signal transducer and activator of transcription 2, 113kDa	Affinity Capture-Western	BioGRID	12244326
STMN2	SCG10 \| SCGN10 \| SGC10	stathmin-like 2	BAF170 interacts with SCG10 promoter.	BIND	15035981

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_REG_GR_PATHWAY	82	60	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP	380	215	All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_DN	86	47	All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN	406	230	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	195	138	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	390	242	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP	45	33	All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_UP	41	26	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-150	220	226	1A	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.