Gene Page: SMARCE1

Summary
GeneID  6605
Symbol  SMARCE1
Synonyms  BAF57
Description  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
See related  HGNC:11109|MIM:603111|Ensembl:ENSG00000073584|HPRD:04382|
Locus tag  -
Gene type  protein-coding
Map location  17q21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0447 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PPP1R12B0.850.84
AP000751.30.830.81
HECW20.820.82
CDYL20.820.80
SIK20.820.80
PLEKHM30.810.82
ZFP1060.810.83
CPEB30.810.83
DLGAP10.810.76
C17orf510.800.79
Top 10 negatively co-expressed genes
C1orf61-0.48-0.57
RHOC-0.48-0.56
AF347015.21-0.47-0.49
DBI-0.47-0.54
C1orf54-0.46-0.53
SYCP3-0.46-0.51
C16orf74-0.45-0.47
IL32-0.44-0.53
RAB34-0.44-0.50
AL050337.1-0.44-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003682chromatin bindingTAS9435219 
GO:0003713transcription coactivator activityTAS9435219 
GO:0008080N-acetyltransferase activityIDA12192000 
GO:0047485protein N-terminus bindingIPI12917342 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006337nucleosome disassemblyTAS9435219 
GO:0006357regulation of transcription from RNA polymerase II promoterTAS9435219 
GO:0016568chromatin modificationIEA-
GO:0045892negative regulation of transcription, DNA-dependentIDA12192000 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000228nuclear chromosomeTAS9435219 
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA18029348 
GO:0017053transcriptional repressor complexIPI12192000 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, betaAffinity Capture-WesternBioGRID9845365 
ACTL6AACTL6 | Arp4 | BAF53A | INO80K | MGC5382actin-like 6AAffinity Capture-WesternBioGRID9845365 
BAZ1BWBSCR10 | WBSCR9 | WSTFbromodomain adjacent to zinc finger domain, 1B-HPRD,BioGRID12837248 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1An unspecified isoform of DISC1 interacts with SMARCE1.BIND14623284 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID12145209 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)-HPRD,BioGRID12145209 
GATA1ERYF1 | GF-1 | GF1 | NFE1GATA binding protein 1 (globin transcription factor 1)Reconstituted ComplexBioGRID11018012 
KLF1EKLFKruppel-like factor 1 (erythroid)Reconstituted ComplexBioGRID11018012 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID12145209 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3-HPRD12145209 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID12917342 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD9710619 
RELBI-REL | IRELv-rel reticuloendotheliosis viral oncogene homolog BAffinity Capture-MSBioGRID14743216 
SMARCA2BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Co-purificationBioGRID8895581 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Affinity Capture-Western
Co-purification		BioGRID8895581 |9845365 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-Western
Co-purification		BioGRID8895581 |9845365 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Affinity Capture-WesternBioGRID9845365 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Affinity Capture-WesternBioGRID9845365 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD12145209 
STAT2ISGF-3 | MGC59816 | P113 | STAT113signal transducer and activator of transcription 2, 113kDaAffinity Capture-WesternBioGRID12244326 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Reconstituted ComplexBioGRID11018012 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ERB_GENOMIC_PATHWAY 158All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN 165104All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON 13378All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
PARK_HSC_AND_MULTIPOTENT_PROGENITORS 5033All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_4HR 5436All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN 4630All SZGR genes in this pathway
GYORFFY_MITOXANTRONE_RESISTANCE 5735All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
KIM_TIAL1_TARGETS 3222All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1072922991A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-49410301036m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-97307361Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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