Gene Page: SMN1

Summary
GeneID  6606
Symbol  SMN1
Synonyms  BCD541|SMA|SMA1|SMA2|SMA3|SMA4|SMA@|SMN|SMNT|T-BCD541
Description  survival of motor neuron 1, telomeric
See related  HGNC:11117|MIM:600354|Ensembl:ENSG00000172062|HPRD:02646|
Locus tag  -
Gene type  protein-coding
Map location  5q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1944 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TCF120.870.88
NARG20.860.84
HAUS60.850.88
EPB41L50.840.81
TULP30.840.76
CDO10.840.77
TMEM194A0.840.84
DHX400.830.85
C6orf1670.830.82
PRKD30.830.79
Top 10 negatively co-expressed genes
MT-CO2-0.54-0.74
AF347015.31-0.53-0.71
FXYD1-0.53-0.71
IFI27-0.51-0.70
C5orf53-0.51-0.63
CXCL14-0.51-0.72
AF347015.33-0.51-0.67
AF347015.27-0.50-0.67
MYL3-0.50-0.70
AF347015.21-0.50-0.74
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3Two-hybridBioGRID16169070 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID9389483 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
COILCLN80 | p80-coilincoilin-HPRD,BioGRID11641277 |12361597 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
DDX20DKFZp434H052 | DP103 | GEMIN3DEAD (Asp-Glu-Ala-Asp) box polypeptide 20-HPRD,BioGRID10601333 
DHX9DDX9 | LKP | NDHII | RHADEAH (Asp-Glu-Ala-His) box polypeptide 9-HPRD,BioGRID11149922 
FBLFIB | FLRN | RNU3IP1fibrillarinAffinity Capture-Western
Co-localization
Reconstituted Complex
BioGRID11509230 
FUBP1FBP | FUBPfar upstream element (FUSE) binding protein 1-HPRD,BioGRID10734235 
GAR1NOLA1GAR1 ribonucleoprotein homolog (yeast)-HPRD,BioGRID11509230 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
GEMIN4DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97gem (nuclear organelle) associated protein 4Affinity Capture-Western
Co-fractionation
Co-purification
BioGRID10942426 |12668731 
GEMIN5DKFZp586M1824 | MGC142174gem (nuclear organelle) associated protein 5-HPRD,BioGRID11714716 
GEMIN6FLJ23459gem (nuclear organelle) associated protein 6Affinity Capture-WesternBioGRID11748230 
GEMIN7SIP3gem (nuclear organelle) associated protein 7-HPRD,BioGRID12065586 
HNRNPRFLJ25714 | HNRPR | hnRNP-Rheterogeneous nuclear ribonucleoprotein R-HPRD,BioGRID11574476 |11773003 
KPNB1IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97karyopherin (importin) beta 1-HPRD,BioGRID12095920 
LENG8KIAA1932 | MGC40108 | pp13842leukocyte receptor cluster (LRC) member 8Two-hybridBioGRID16189514 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1Affinity Capture-WesternBioGRID11522829 
LSM1CASM | YJL124CLSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD10851237 
LSM11FLJ38273LSM11, U7 small nuclear RNA associated-HPRD12975319 
LSM2C6orf28 | G7b | YBL026W | snRNPLSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID10851237 
LSM3SMX4 | USS2 | YLR438CLSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD10851237 
LSM4YER112WLSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID10851237 
LSM5FLJ12710 | YER146WLSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD10851237 
LSM6YDR378CLSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID10851237 
LSM7YNL147WLSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID10851237 
OSTF1FLJ20559 | OSF | SH3P2 | bA235O14.1osteoclast stimulating factor 1-HPRD11551898 
POP70610037N12Rik | RPP2 | RPP20processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)Rpp20 interacts with SMNBIND14715275 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunitAffinity Capture-WesternBioGRID12668731 
SIP1GEMIN2 | SIP1-deltasurvival of motor neuron protein interacting protein 1-HPRD,BioGRID9323129 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomericTwo-hybridBioGRID16189514 
hSMN interacts with a second hSMN molecule.BIND14715275 
SMN2BCD541 | C-BCD541 | FLJ76644 | MGC20996 | MGC5208 | SMNCsurvival of motor neuron 2, centromericCo-fractionation
Co-purification
BioGRID10942426 
SNRPBCOD | SNRPB1 | SmB/SmB' | snRNP-Bsmall nuclear ribonucleoprotein polypeptides B and B1SMN interacts with SmB'.BIND15494309 
-HPRD11720283 
-HPRD,BioGRID9323129|11720283 
SNRPD1HsT2456 | SMD1 | SNRPDsmall nuclear ribonucleoprotein D1 polypeptide 16kDaCo-fractionation
Co-purification
Reconstituted Complex
BioGRID9323129 |10851237 
|10942426 
SNRPD2SMD2 | SNRPD1small nuclear ribonucleoprotein D2 polypeptide 16.5kDaCo-fractionation
Co-purification
BioGRID10942426 
SNRPD3SMD3small nuclear ribonucleoprotein D3 polypeptide 18kDaReconstituted ComplexBioGRID10851237 
SNRPEB-raf | SMEsmall nuclear ribonucleoprotein polypeptide EReconstituted ComplexBioGRID9323129 
SNUPNKPNBL | RNUT1 | Snurportin1snurportin 1Reconstituted ComplexBioGRID12095920 
STXBP3MUNC18-3 | MUNC18C | PSP | UNC-18Csyntaxin binding protein 3-HPRD12065586 
SYNCRIPGRY-RBP | HNRPQ1 | NSAP1 | RP1-3J17.2 | dJ3J17.2 | hnRNP-Q | pp68synaptotagmin binding, cytoplasmic RNA interacting protein-HPRD11773003 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11704667 
UNC119HRG4unc-119 homolog (C. elegans)Two-hybridBioGRID16169070 
WDYHV1C8orf32 | FLJ10204WDYHV motif containing 1Two-hybridBioGRID16189514 
ZRANB2DKFZp686J1831 | DKFZp686N09117 | FLJ41119 | ZIS | ZIS1 | ZIS2 | ZNF265zinc finger, RAN-binding domain containing 2-HPRD11448987 
 
Pathway annotation


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