Gene Page: SOS1

Summary
GeneID  6654
Symbol  SOS1
Synonyms  GF1|GGF1|GINGF|HGF|NS4
Description  son of sevenless homolog 1 (Drosophila)
See related  HGNC:11187|MIM:182530|Ensembl:ENSG00000115904|HPRD:01681|
Locus tag  -
Gene type  protein-coding
Map location  2p22-p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0409 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005100Rho GTPase activator activityTAS9790532 
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005089Rho guanyl-nucleotide exchange factor activityTAS9790532 
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI9690470 |10206341 |12029088 
|14679214 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007265Ras protein signal transductionEXP11520933 
GO:0007265Ras protein signal transductionTAS8493579 
GO:0007165signal transductionNAS8493579 
GO:0035023regulation of Rho protein signal transductionIEA-
GO:0051056regulation of small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7739560 |8479541 |8493579 
|8810325 |9690470 
GO:0005622intracellularIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI1ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1abl-interactor 1-HPRD,BioGRID10499589 
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-WesternBioGRID8112292 
ANXA2ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36 | PAP-IVannexin A2Reconstituted ComplexBioGRID7510700 
ATP6V1E1ATP6E | ATP6E2 | ATP6V1E | P31 | Vma4ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1-HPRD11560919 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-WesternBioGRID8112292 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID8810325 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD9162067 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9447973 
EPS8-epidermal growth factor receptor pathway substrate 8Affinity Capture-WesternBioGRID10499589 |14565974 
EPS8L1DRC3 | EPS8R1 | FLJ20258 | MGC23164 | MGC4642 | PP10566EPS8-like 1-HPRD,BioGRID14565974 
EPS8L2EPS8R2 | FLJ16738 | FLJ21935 | FLJ22171 | MGC126530 | MGC3088EPS8-like 2Affinity Capture-WesternBioGRID14565974 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD11173924 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD11173924 
FRS2FRS2A | FRS2alpha | SNT | SNT-1 | SNT1fibroblast growth factor receptor substrate 2-HPRD,BioGRID9182757 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9856337 
GAB1-GRB2-associated binding protein 1Gab1 interacts with Sos1. This interaction was modeled on a demonstrated interaction between Gab1 from an unknown species and human Sos1.BIND11707404 
GRAPMGC64880GRB2-related adaptor protein-HPRD,BioGRID8647802 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.BIND8112292 
-HPRD8479541 |8493579 
Affinity Capture-MS
Affinity Capture-Western
Far Western
Reconstituted Complex
Two-hybrid
BioGRID7510700 |7514169 
|7629168 |7664271 
|8112292 |8188688 
|8479541 |8695800 
|8810325 |9009162 
|9344843 |9872323 
|10207103 |10319320 
|10477741 |10570290 
|10716926 |11960376 
|11964172 |11997436 
|12577067 
GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.BIND7862111 
Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.BIND9374537 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD9690470 |11560935 
Co-crystal StructureBioGRID9690470 |12628188 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)-HPRD,BioGRID10716926 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)Affinity Capture-WesternBioGRID9660480 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associated-HPRD,BioGRID7664271 |11278868 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1NCK interacts with SOS. This interaction was modeled on a demonstrated interaction between human NCK and mouse SOS or hamster SOS.BIND7862111 
-HPRD7862111 |10026169 
|10206341 
Affinity Capture-Western
Reconstituted Complex
BioGRID7862111 |8810325 
|10026169 |10206341 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID10026169 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)Affinity Capture-WesternBioGRID10675333 
PACSIN1KIAA1379 | SDPIprotein kinase C and casein kinase substrate in neurons 1-HPRD11352907 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID10913276 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-WesternBioGRID9344843 |9632781 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6Affinity Capture-WesternBioGRID8632004 
RIT2RIBA | RIN | ROC2Ras-like without CAAX 2-HPRD,BioGRID12099688 
RRAS-related RAS viral (r-ras) oncogene homolog-HPRD11560935 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD,BioGRID11071869 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-WesternBioGRID9344843 |10570290 
|10675333 |10783152 
SNX18FLJ11997 | FLJ32560 | MGC150827 | MGC150829 | SH3PX2 | SH3PXD3B | SNAG1sorting nexin 18-HPRD14679214 
SNX9MST155 | MSTP155 | SDP1 | SH3PX1 | SH3PXD3A | WISPsorting nexin 9-HPRD14679214 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD7629168 
 


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