Gene Page: SPI1

Summary
GeneID  6688
Symbol  SPI1
Synonyms  OF|PU.1|SFPI1|SPI-1|SPI-A
Description  spleen focus forming virus (SFFV) proviral integration oncogene spi1
See related  HGNC:11241|MIM:165170|Ensembl:ENSG00000066336|HPRD:01305|
Locus tag  hCG_25181
Gene type  protein-coding
Map location  11p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PSMA40.870.87
UTP11L0.870.87
PSMA30.870.86
C4orf270.870.88
EAPP0.860.86
PPHLN10.860.86
PAK1IP10.850.85
C6orf1620.850.83
BXDC20.850.86
DDX500.850.84
Top 10 negatively co-expressed genes
AF347015.2-0.74-0.70
MT-CYB-0.73-0.70
MT-CO2-0.73-0.67
AF347015.8-0.73-0.68
AF347015.15-0.72-0.70
AF347015.26-0.72-0.70
AF347015.33-0.72-0.68
AF347015.27-0.70-0.68
AF347015.31-0.69-0.67
AF347015.9-0.66-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityTAS2180582 |10867017 
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI10207087 
GO:0016563transcription activator activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043011myeloid dendritic cell differentiationIEAdendrite (GO term level: 10)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS10867017 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0030098lymphocyte differentiationIEA-
GO:0006350transcriptionIEA-
GO:0043193positive regulation of gene-specific transcriptionIDA12833137 
GO:0030851granulocyte differentiationIEA-
GO:0030225macrophage differentiationIEA-
GO:0045646regulation of erythrocyte differentiationIMP12833137 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF1EWS-ATF1 | FUS/ATF-1 | TREB36activating transcription factor 1-HPRD,BioGRID7730336 
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alpha-HPRD,BioGRID12091339 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID7594592 
CEBPEC/EBP-epsilon | CRP1CCAAT/enhancer binding protein (C/EBP), epsilonC/EBP-epsilon interacts with PU.1.BIND12202480 
CREMICER | MGC111110 | MGC17881 | MGC41893 | hCREM-2cAMP responsive element modulator-HPRD,BioGRID7730336 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptideBiochemical ActivityBioGRID8632909 
ERGerg-3 | p55v-ets erythroblastosis virus E26 oncogene homolog (avian)-HPRD9681824 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Reconstituted ComplexBioGRID9681824 
ETS2ETS2IT1v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Reconstituted ComplexBioGRID9681824 
ETV1DKFZp781L0674 | ER81 | MGC104699 | MGC120533 | MGC120534ets variant 1Reconstituted ComplexBioGRID9681824 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologReconstituted ComplexBioGRID9681824 
FUSCHOP | FUS-CHOP | FUS1 | TLS | TLS/CHOP | hnRNP-P2fusion (involved in t(12;16) in malignant liposarcoma)-HPRD,BioGRID9478924 
GATA1ERYF1 | GF-1 | GF1 | NFE1GATA binding protein 1 (globin transcription factor 1)PU.1 interacts with GATA-1.BIND12202480 
GATA2MGC2306 | NFE1BGATA binding protein 2-HPRD,BioGRID10411939 
IRF4LSIRF | MUM1interferon regulatory factor 4-HPRD,BioGRID10022840 |12372320 
IRF8H-ICSBP | ICSBP | ICSBP1 | IRF-8interferon regulatory factor 8-HPRD10734131 
JUNAP-1 | AP1 | c-Junjun oncogeneReconstituted ComplexBioGRID9681824 
-HPRD12091339 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Biochemical ActivityBioGRID8632909 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factor-HPRD,BioGRID9918847 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD9094628 
NFYACBF-A | CBF-B | FLJ11236 | HAP2 | NF-YAnuclear transcription factor Y, alphaReconstituted ComplexBioGRID9668064 
NONONMT55 | NRB54 | P54 | P54NRBnon-POU domain containing, octamer-binding-HPRD,BioGRID8626664 
PRG2BMPG | MBP | MBP1 | MGC14537proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)The MBP-P2 promoter interacts with PU.1.BIND12202480 
SPIBSPI-BSpi-B transcription factor (Spi-1/PU.1 related)-HPRD,BioGRID10196196 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN 6638All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_8 3628All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION 3021All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_RARA_PLZF_FUSION 2214All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ZHAN_EARLY_DIFFERENTIATION_GENES_DN 4229All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_UP 4126All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN 6845All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15546531A,m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-33973791Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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