Gene Page: BRCA2

Summary
GeneID  675
Symbol  BRCA2
Synonyms  BRCC2|FACD|FAD|FAD1|FANCB|FANCD|FANCD1
Description  breast cancer 2, early onset
See related  HGNC:1101|MIM:600185|Ensembl:ENSG00000139618|HPRD:02554|
Locus tag  RP11-298P3.4
Gene type  protein-coding
Map location  13q12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0542 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003697single-stranded DNA bindingIEA-
GO:0005515protein bindingIPI9774970 |10373512 |11597317 
|12242698 |15930293 
|15967112 |16099937 
|16275750 |17515903 
GO:0004402histone acetyltransferase activityIDA9824164 
GO:0016563transcription activator activityIDA9619837 
GO:0043015gamma-tubulin bindingIPI17286961 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0001556oocyte maturationIEA-
GO:0000724double-strand break repair via homologous recombinationIEA-
GO:0001833inner cell mass cell proliferationIEA-
GO:0006355regulation of transcription, DNA-dependentIC9619837 
GO:0007141male meiosis IIEA-
GO:0006310DNA recombinationIEA-
GO:0008585female gonad developmentIEA-
GO:0006289nucleotide-excision repairIMP16845393 
GO:0007283spermatogenesisIEA-
GO:0007090regulation of S phase of mitotic cell cycleNAS9774970 
GO:0010225response to UV-CIEA-
GO:0010165response to X-rayIEA-
GO:0010332response to gamma radiationIEA-
GO:0048478replication fork protectionIEA-
GO:0007569cell agingIEA-
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIEA-
GO:0033595response to genisteinIDA16434996 
GO:0033600negative regulation of mammary gland epithelial cell proliferationIDA15930293 
GO:0033205cytokinesis during cell cycleIDA17286961 
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisIEA-
GO:0043009chordate embryonic developmentIEA-
GO:0051298centrosome duplicationIDA17286961 
GO:0051276chromosome organizationIEA-
GO:0045931positive regulation of mitotic cell cycleIEA-
GO:0043627response to estrogen stimulusIDA8895509 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA17286961 
GO:0005634nucleusIDA9560268 |9774970 |17286961 
GO:0005654nucleoplasmEXP12606939 
GO:0005737cytoplasmIEA-
GO:0033593BRCA2-MAGE-D1 complexIDA15930293 
GO:0030141secretory granuleIDA8589722 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedReconstituted ComplexBioGRID15199141 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
BARD1-BRCA1 associated RING domain 1Co-purification
Reconstituted Complex		BioGRID14636569 
BCCIPTOK-1 | TOK1BRCA2 and CDKN1A interacting protein-HPRD,BioGRID11313963 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID9774970 
BRCA1 interacts with BRCA2.BIND9774970 
BRCC3BRCC36 | C6.1A | CXorf53BRCA1/BRCA2-containing complex, subunit 3Affinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID14636569 
BREBRCC4 | BRCC45brain and reproductive organ-expressed (TNFRSF1A modulator)Affinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID14636569 
BUB1BBUB1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1budding uninhibited by benzimidazoles 1 homolog beta (yeast)-HPRD,BioGRID10749118 
C11orf30EMSY | FLJ90741 | GL002chromosome 11 open reading frame 30-HPRD,BioGRID14651845 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID17525332 
FANCD2DKFZp762A223 | FA-D2 | FA4 | FACD | FAD | FAD2 | FANCD | FLJ23826Fanconi anemia, complementation group D2Affinity Capture-Western
Co-localization
Two-hybrid		BioGRID15115758 |15199141 
FANCD2 interacts with BRCA2.BIND15115758 
FANCEFACE | FAEFanconi anemia, complementation group EAffinity Capture-WesternBioGRID15199141 
FANCGFAG | XRCC9Fanconi anemia, complementation group GAffinity Capture-Western
Two-hybrid		BioGRID12915460 
FANCG interacts with BRCA2.BIND12915460 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD,BioGRID11602572 
BRCA2 interacts with hsFLNa.BIND11602572 
HMG20BBRAF25 | BRAF35 | FLJ26127 | HMGX2 | PP7706 | SMARCE1r | SOXL | pp8857high-mobility group 20B-HPRD,BioGRID11207365 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD,BioGRID9824164 
PLK1PLK | STPK13polo-like kinase 1 (Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID12815053 |14647413 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)Affinity Capture-MS
Affinity Capture-Western
Co-localization
Co-purification
Reconstituted Complex
Two-hybrid		BioGRID9126738 |9405383 
|9523196 |9560268 
|9774970 |9811893 
|11313963 |11477095 
|12408834 |12442171 
|12815053 |14580352 
|14636569 |15065660 
-HPRD9126738 |12619154 
BRCA2 interacts with RAD51.BIND9774970 
BRCA2 interacts with Rad51.BIND9774970 
BRCA2 interacts with an unspecified isoform of RAD51.BIND15800615 
RPA1HSSB | REPA1 | RF-A | RP-A | RPA70replication protein A1, 70kDaAffinity Capture-Western
Reconstituted Complex		BioGRID12527904 
SHFM1DSS1 | ECD | SEM1 | SHFD1 | SHSF1 | Shfdg1split hand/foot malformation (ectrodactyly) type 1-HPRD,BioGRID10373512 |12228710 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2Affinity Capture-WesternBioGRID12165866 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3SMAD3 interacts with BRCA2.BIND12165866 
-HPRD,BioGRID12165866 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID12459499 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID9811893 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HOMOLOGOUS_RECOMBINATION 2817All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
BIOCARTA_ATRBRCA_PATHWAY 2112All SZGR genes in this pathway
PID_FANCONI_PATHWAY 4728All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_ATR_PATHWAY 3925All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_DELTA_NP63_PATHWAY 4734All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 1711All SZGR genes in this pathway
REACTOME_FANCONI_ANEMIA_PATHWAY 2511All SZGR genes in this pathway
REACTOME_DOUBLE_STRAND_BREAK_REPAIR 2414All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_MEIOTIC_RECOMBINATION 8662All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN 6642All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN 4525All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MATHEW_FANCONI_ANEMIA_GENES 117All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
KUROKAWA_LIVER_CANCER_CHEMOTHERAPY_DN 4128All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
YU_MYC_TARGETS_UP 4226All SZGR genes in this pathway
PARK_HSC_AND_MULTIPOTENT_PROGENITORS 5033All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_DN 2314All SZGR genes in this pathway
ZHU_CMV_8_HR_UP 4739All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MATZUK_SPERMATOCYTE 7255All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_UP 212128All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway


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