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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: STX5

Summary

GeneID

6811

Symbol

STX5

Synonyms

SED5|STX5A

Description

syntaxin 5

Locus tag

Gene type

protein-coding

Map location

11q12.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005484

SNAP receptor activity

IDA

15215310

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006903

vesicle targeting

TAS

9188044

GO:0006886

intracellular protein transport

IEA

GO:0042147

retrograde transport, endosome to Golgi

IDA

15215310

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0031201

SNARE complex

TAS

neuron, Synap (GO term level: 6)

15215310

GO:0000139

Golgi membrane

IEA

GO:0005794

Golgi apparatus

IDA

15215310

GO:0005634

nucleus

IDA

18029348

GO:0005730

nucleolus

IDA

18029348

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

GO:0033116

ER-Golgi intermediate compartment membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APLP1	APLP	amyloid beta (A4) precursor-like protein 1	Two-hybrid	BioGRID	16169070
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B associated transcript 3	Two-hybrid	BioGRID	16169070
BET1	DKFZp781C0425 \| HBET1	blocked early in transport 1 homolog (S. cerevisiae)	-	HPRD	9094723
BET1	DKFZp781C0425 \| HBET1	blocked early in transport 1 homolog (S. cerevisiae)	Affinity Capture-Western	BioGRID	11927603
BET1L	BET1L1 \| GOLIM3 \| GS15 \| HSPC197	blocked early in transport 1 homolog (S. cerevisiae)-like	Affinity Capture-Western	BioGRID	11927603 \|12388752
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
COPS6	CSN6 \| MOV34-34KD	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	Two-hybrid	BioGRID	16169070
GOSR1	GOLIM2 \| GOS-28 \| GOS28 \| GOS28/P28 \| GS28 \| P28	golgi SNAP receptor complex member 1	-	HPRD,BioGRID	9094723
GOSR2	Bos1 \| GS27	golgi SNAP receptor complex member 2	Affinity Capture-Western Co-purification Two-hybrid	BioGRID	9094723 \|9647643 \|11927603
GOSR2	Bos1 \| GS27	golgi SNAP receptor complex member 2	-	HPRD	9094723 \|9647643\|11035026
HAP1	HAP2 \| HIP5 \| HLP \| hHLP1	huntingtin-associated protein 1	Two-hybrid	BioGRID	16169070
IMMT	DKFZp779P1653 \| HMP \| MGC111146 \| P87 \| P87/89 \| P89 \| PIG4 \| PIG52	inner membrane protein, mitochondrial (mitofilin)	Two-hybrid	BioGRID	16169070
NAPA	SNAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	Reconstituted Complex Two-hybrid	BioGRID	9506515 \|16189514
NSFL1C	MGC3347 \| UBX1 \| UBXD10 \| UBXN2C \| dJ776F14.1 \| p47	NSFL1 (p97) cofactor (p47)	-	HPRD	9506515
NSFL1C	MGC3347 \| UBX1 \| UBXD10 \| UBXN2C \| dJ776F14.1 \| p47	NSFL1 (p97) cofactor (p47)	-	HPRD,BioGRID	9506515\|12473691
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	The full-length PS1 holoprotein interacts with Syntaxin 5.	BIND	15109302
SCFD1	C14orf163 \| KIAA0917 \| RA410 \| SLY1 \| STXBP1L2	sec1 family domain containing 1	-	HPRD	12506202 \|14565970
SEC22A	SEC22L2	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)	Affinity Capture-Western	BioGRID	11927603
SEC22B	ERS-24 \| SEC22L1	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)	-	HPRD	11035026
SEC22B	ERS-24 \| SEC22L1	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)	Affinity Capture-Western	BioGRID	15029241
SNAP23	HsT17016 \| SNAP23A \| SNAP23B	synaptosomal-associated protein, 23kDa	Reconstituted Complex	BioGRID	12651853
SNAP25	FLJ23079 \| RIC-4 \| RIC4 \| SEC9 \| SNAP \| SNAP-25 \| bA416N4.2 \| dJ1068F16.2	synaptosomal-associated protein, 25kDa	Reconstituted Complex	BioGRID	9325254
STX17	FLJ20651 \| MGC102796 \| MGC126613 \| MGC126615	syntaxin 17	Co-purification	BioGRID	9094723
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	16169070
USO1	P115 \| TAP \| VDP	USO1 homolog, vesicle docking protein (yeast)	-	HPRD,BioGRID	11927603
VAPB	ALS8 \| VAMP-B \| VAMP-C \| VAP-B \| VAP-C	VAMP (vesicle-associated membrane protein)-associated protein B and C	Reconstituted Complex	BioGRID	12651853
VCP	IBMPFD \| MGC131997 \| MGC148092 \| MGC8560 \| TERA \| p97	valosin-containing protein	-	HPRD	9506515
VCPIP1	DKFZp686G038 \| DUBA3 \| FLJ23132 \| FLJ60694 \| KIAA1850 \| VCIP135	valosin containing protein (p97)/p47 complex interacting protein 1	-	HPRD	12473691
VTI1B	VTI1 \| VTI1-LIKE \| VTI1L \| VTI2	vesicle transport through interaction with t-SNAREs homolog 1B (yeast)	Affinity Capture-Western	BioGRID	11927603
YKT6	-	YKT6 v-SNARE homolog (S. cerevisiae)	Affinity Capture-Western	BioGRID	11927603

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	38	25	All SZGR genes in this pathway
REACTOME_BOTULINUM_NEUROTOXICITY	19	14	All SZGR genes in this pathway
REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS	17	12	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN	634	384	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN	214	133	All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN	11	8	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN	394	258	All SZGR genes in this pathway
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA	103	58	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN	98	59	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_8HR_5_UP	16	7	All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN	81	51	All SZGR genes in this pathway
UEDA_CENTRAL_CLOCK	88	62	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP	439	257	All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_UP	41	26	All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP	245	159	All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP	293	203	All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN	138	99	All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN	225	124	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-133	404	411	1A,m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	404	411	1A,m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-150	91	98	1A,m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-182	518	524	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-24	72	78	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-24	72	78	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-27	232	238	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	232	238	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-431	555	561	m8	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-485-5p	565	571	m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-96	518	524	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.