Gene Page: BTC

Summary
GeneID  685
Symbol  BTC
Synonyms  -
Description  betacellulin
See related  HGNC:1121|MIM:600345|Ensembl:ENSG00000174808|HPRD:02643|
Locus tag  -
Gene type  protein-coding
Map location  4q13-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.409 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RPL50.970.94
RPL40.960.97
NACA0.960.96
ILF20.960.95
IGBP10.960.96
TUT10.960.90
EIF3H0.960.93
C14orf1660.960.92
RPS80.950.86
VPS720.950.93
Top 10 negatively co-expressed genes
HLA-F-0.69-0.76
AIFM3-0.67-0.74
AF347015.27-0.66-0.82
FBXO2-0.66-0.66
AF347015.33-0.65-0.83
C5orf53-0.65-0.66
MT-CO2-0.64-0.81
TINAGL1-0.64-0.76
ATP10A-0.64-0.72
MT-CYB-0.64-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005154epidermal growth factor receptor bindingTAS8144591 
GO:0008083growth factor activityTAS8439318 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008284positive regulation of cell proliferationTAS8144591 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS8144591 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD9528863 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD9662041 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)-HPRD11254912 
MMP9CLG4B | GELB | MMP-9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)-HPRD10706134 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_ERBB_NETWORK_PATHWAY 1513All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 2017All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3 12868All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-37877831Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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