Gene Page: SYK

Summary
GeneID  6850
Symbol  SYK
Synonyms  DKFZp313N1010|FLJ25043|FLJ37489
Description  spleen tyrosine kinase
See related  HGNC:11491|MIM:600085|Ensembl:ENSG00000165025|HPRD:02514|
Locus tag  -
Gene type  protein-coding
Map location  9q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IRF90.930.87
PARP90.890.81
IFITM30.880.79
OAS10.880.75
IFI350.870.81
IFIT30.870.83
PSMB80.870.83
BATF20.870.78
PLSCR10.870.74
MT1E0.860.84
Top 10 negatively co-expressed genes
RTF1-0.61-0.71
PHF14-0.57-0.74
NOL4-0.56-0.69
DPF1-0.56-0.70
PDCD11-0.56-0.66
SH3BP5-0.55-0.66
REV1-0.55-0.66
RNASEN-0.55-0.68
SAFB-0.55-0.66
HEATR5B-0.55-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004716receptor signaling protein tyrosine kinase activityIEA-
GO:0005178integrin bindingIPI12885943 
GO:0005515protein bindingIPI8627166 |9280292 |12885943 
GO:0005524ATP bindingIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001820serotonin secretionIEAneuron, serotonin (GO term level: 7)-
GO:0006461protein complex assemblyTAS8163536 
GO:0007257activation of JNK activityIEA-
GO:0007242intracellular signaling cascadeIEA-
GO:0007229integrin-mediated signaling pathwayNAS12885943 
GO:0009887organ morphogenesisTAS7477352 
GO:0007167enzyme linked receptor protein signaling pathwayIEA-
GO:0008283cell proliferationTAS10963601 
GO:0007159leukocyte adhesionIDA12885943 
GO:0019370leukotriene biosynthetic processIEA-
GO:0030593neutrophil chemotaxisIDA12885943 
GO:0043366beta selectionIEA-
GO:0043306positive regulation of mast cell degranulationIEA-
GO:0045579positive regulation of B cell differentiationIEA-
GO:0045588positive regulation of gamma-delta T cell differentiationIEA-
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0050850positive regulation of calcium-mediated signalingIEA-
GO:0044419interspecies interaction between organismsIEA-
GO:0046638positive regulation of alpha-beta T cell differentiationIEA-
GO:0046641positive regulation of alpha-beta T cell proliferationIEA-
GO:0046777protein amino acid autophosphorylationIEA-
GO:0045401positive regulation of interleukin-3 biosynthetic processIEA-
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic processIEA-
GO:0050853B cell receptor signaling pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019815B cell receptor complexIEASynap (GO term level: 8)-
GO:0042101T cell receptor complexIDASynap (GO term level: 8)8176201 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneEXP9280292 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD10981967 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-Western
Reconstituted Complex		BioGRID9857068 |11331248 
|12435267 
-HPRD9857068 |10540342 
|11133830 
CD19B4 | MGC12802CD19 molecule-HPRD,BioGRID9120258 
CD22FLJ22814 | MGC130020 | SIGLEC-2 | SIGLEC2CD22 molecule-HPRD,BioGRID8627166 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)Reconstituted ComplexBioGRID7761456 
CD72CD72b | LYB2CD72 moleculeBiochemical ActivityBioGRID9590210 
CD79AIGA | MB-1CD79a molecule, immunoglobulin-associated alpha-HPRD,BioGRID1569106|7500027 
CD79BB29 | IGBCD79b molecule, immunoglobulin-associated betaReconstituted ComplexBioGRID7500027 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-likeCrkL interacts with Syk.BIND11313252 
-HPRD,BioGRID11313252 
CSF3RCD114 | GCSFRcolony stimulating factor 3 receptor (granulocyte)-HPRD,BioGRID8197119 
CTTNEMS1 | FLJ34459cortactin-HPRD,BioGRID8636079 
EPORMGC138358erythropoietin receptor-HPRD,BioGRID9852052 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinSyk interacts with ezrin. This interaction was modeled on a demonstrated interaction between Syk and ezrin from unspecified species.BIND12387735 
FCER1GFCRGFc fragment of IgE, high affinity I, receptor for; gamma polypeptide-HPRD,BioGRID8071371 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)-HPRD,BioGRID11141335 
FCGR2ACD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032Fc fragment of IgG, low affinity IIa, receptor (CD32)Reconstituted ComplexBioGRID9268059 
FCRL3FCRH3 | IFGP3 | IRTA3 | SPAP2Fc receptor-like 3Reconstituted ComplexBioGRID12051764 
FGRFLJ43153 | MGC75096 | SRC2 | c-fgr | c-src2 | p55c-fgr | p58c-fgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog-HPRD,BioGRID11672534 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9535867 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID11964172 
ITGB2CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Affinity Capture-WesternBioGRID10961871 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD10825200 
LATLAT1 | pp36linker for activation of T cellsBiochemical ActivityBioGRID11368773 
-HPRD9891970 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID7539035 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD15388330 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID7831290 
MS4A2APY | ATOPY | FCER1B | FCERI | IGEL | IGER | IGHER | MS4A1membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)-HPRD,BioGRID8071371 
MSN-moesinSyk interacts with moesin. This interaction was modeled on a demonstrated interaction between Syk and moesin from unspecified species.BIND12387735 
NFAM1CNAIP | FLJ40652 | bK126B4.4NFAT activating protein with ITAM motif 1-HPRD15143214 
PAG1CBP | FLJ37858 | MGC138364 | PAGphosphoprotein associated with glycosphingolipid microdomains 1-HPRD,BioGRID10790433 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Affinity Capture-WesternBioGRID7831290 
-HPRD8885868 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)Affinity Capture-WesternBioGRID10981967 
PRKD1PKC-MU | PKCM | PKD | PRKCMprotein kinase D1Affinity Capture-WesternBioGRID8885868 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID9169439 |9342235 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10747947 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6Affinity Capture-Western
Biochemical Activity		BioGRID10072516 |10747947 
-HPRD10072516 |11356834 
PXNFLJ16691paxillin-HPRD,BioGRID9590268 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Biochemical ActivityBioGRID16640565 
RPS6KB2KLS | P70-beta | P70-beta-1 | P70-beta-2 | S6K-beta2 | S6K2 | SRK | STK14B | p70(S6K)-beta | p70S6Kbribosomal protein S6 kinase, 70kDa, polypeptide 2Biochemical ActivityBioGRID16640565 
SH2B2APSSH2B adaptor protein 2-HPRD10872802 
SH3BP23BP2 | CRBM | CRPM | FLJ42079 | RES4-23SH3-domain binding protein 2-HPRD,BioGRID9846481 |11390470 
SIRPB1CD172b | DKFZp686A05192 | FLJ26614 | SIRP-BETA-1signal-regulatory protein beta 1Affinity Capture-WesternBioGRID10940905 
SIT1MGC125908 | MGC125909 | MGC125910 | RP11-331F9.5 | SITsignaling threshold regulating transmembrane adaptor 1-HPRD,BioGRID10209036 
SLASLA1 | SLAPSrc-like-adaptor-HPRD,BioGRID10449770 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID7513017 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaSyk interacts with and phosphorylates STAT1-alpha.BIND15467722 
Syk interacts with STAT1-beta.BIND15467722 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD10825200 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD10825200 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseSYK autophosphorylates.BIND12477728 
-HPRD,BioGRID9698567 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID11418661 
TUBA1AB-ALPHA-1 | FLJ25113 | LIS3 | TUBA3tubulin, alpha 1a-HPRD,BioGRID10862713 
UBBFLJ25987 | MGC8385ubiquitin BSyk interacts with ubiquitin.BIND11046148 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID8986718 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY 2013All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 3631All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_GMCSF_PATHWAY 3731All SZGR genes in this pathway
PID_NFKAPPAB_ATYPICAL_PATHWAY 1715All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_FAS_PATHWAY 3829All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 2924All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE 3125All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_REGULATION_OF_SIGNALING_BY_CBL 1816All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
PYEON_HPV_POSITIVE_TUMORS_UP 9847All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_DN 8142All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_DN 5735All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
BIDUS_METASTASIS_DN 16193All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_8 187All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN 6447All SZGR genes in this pathway
LIN_APC_TARGETS 7755All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BASSO_CD40_SIGNALING_DN 6844All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_DN 4127All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_4 2112All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN 3623All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_OLD 1310All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_WS 4026All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_WS 3322All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_DN 2112All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_GREEN 1614All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP 2014All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_DN 7945All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_UP 10759All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ZHAN_LATE_DIFFERENTIATION_GENES_DN 1610All SZGR genes in this pathway
GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_2 139All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.