Gene Page: TACR1

Summary
GeneID  6869
Symbol  TACR1
Synonyms  NK1R|NKIR|SPR|TAC1R
Description  tachykinin receptor 1
See related  HGNC:11526|MIM:162323|Ensembl:ENSG00000115353|HPRD:01208|
Locus tag  -
Gene type  protein-coding
Map location  2p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPER0.870.83
FAM38A0.830.84
SLC6A120.810.79
SOX180.800.79
RIN30.790.80
BCAM0.780.81
HLA-E0.780.79
GPR37L10.780.71
COL5A30.770.73
TINAGL10.770.76
Top 10 negatively co-expressed genes
FRG1-0.64-0.71
PSMA4-0.60-0.63
FARSB-0.60-0.60
ASNSD1-0.59-0.59
SPATA7-0.59-0.59
C18orf21-0.59-0.60
COQ3-0.59-0.59
TXNL1-0.58-0.60
GGPS1-0.58-0.56
POLB-0.57-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004995tachykinin receptor activityIEA-
GO:0004995tachykinin receptor activityTAS8985172 
GO:0005515protein bindingIPI17986524 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)TAS1657150 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007217tachykinin signaling pathwayTAS8985172 
GO:0007165signal transductionIEA-
GO:0009582detection of abiotic stimulusTAS9537323 
GO:0006954inflammatory responseTAS10854844 
GO:0007638mechanosensory behaviorTAS9537323 
GO:0048265response to painIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005886plasma membraneTAS10611312 
GO:0005887integral to plasma membraneTAS1657150 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GRK5GPRK5G protein-coupled receptor kinase 5-HPRD,BioGRID12067742 
TAC1Hs.2563 | NK2 | NKNA | NPK | TAC2tachykinin, precursor 1Reconstituted ComplexBioGRID8702757 
-HPRD12548712 
TAC3NKB | NKNB | PRO1155 | ZNEUROK1tachykinin 3-HPRD12727971 
TAC4EK | HK-1 | MGC133009 | MGC133010 | PPT-Ctachykinin 4 (hemokinin)-HPRD11786503 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_UP 3618All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway


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