Gene Page: TBX1

Summary
GeneID  6899
Symbol  TBX1
Synonyms  CAFS|CTHM|DGCR|DGS|DORV|TBX1C|TGA|VCFS
Description  T-box 1
See related  HGNC:11592|MIM:602054|Ensembl:ENSG00000184058|HPRD:09069|
Locus tag  -
Gene type  protein-coding
Map location  22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C4orf480.550.52
MRPS260.530.44
ALDH16A10.520.44
NME40.520.49
NOSIP0.520.42
ZNF7870.520.48
AC018648.10.510.50
HSD17B100.510.39
MRPS340.510.39
C6orf2260.510.42
Top 10 negatively co-expressed genes
UGP2-0.28-0.29
AKTIP-0.27-0.30
GALNTL5-0.27-0.28
CHN1-0.27-0.21
FRG1B-0.27-0.32
EFR3A-0.26-0.29
ZNF365-0.26-0.26
OSBPL1A-0.26-0.25
VSNL1-0.26-0.19
ELL2-0.26-0.26
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA11111039 
GO:0003702RNA polymerase II transcription factor activityNAS9268629 
GO:0042803protein homodimerization activityIDA11111039 
GO:0043565sequence-specific DNA bindingIDA11111039 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterNAS9268629 
GO:0007507heart developmentIMP14585638 
GO:0060037pharyngeal system developmentIMP14585638 
GO:0060017parathyroid gland developmentIMP14585638 
GO:0048703embryonic viscerocranium morphogenesisIMP14585638 
GO:0048538thymus developmentIMP14585638 
GO:0060023soft palate developmentIMP14585638 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA15703190 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN 7444All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
BRUNEAU_SEPTATION_VENTRICULAR 108All SZGR genes in this pathway
BRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS 88All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
KESHELAVA_MULTIPLE_DRUG_RESISTANCE 8856All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1014134191Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1394144211A,m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-1444124191A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1822662721Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-962652721A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.