Gene Page: TCF4

Summary
GeneID  6925
Symbol  TCF4
Synonyms  E2-2|ITF2|MGC149723|MGC149724|PTHS|SEF2|SEF2-1|SEF2-1A|SEF2-1B|bHLHb19
Description  transcription factor 4
See related  HGNC:11634|MIM:602272|Ensembl:ENSG00000196628|HPRD:03780|
Locus tag  -
Gene type  protein-coding
Map location  18q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.26 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA2105528 
GO:0005515protein bindingIPI9824680 |10903890 |11955446 
|16630820 
GO:0046982protein heterodimerization activityNAS2105528 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045893positive regulation of transcription, DNA-dependentIDA2105528 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS1681116 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID12799378 
ASCL1ASH1 | HASH1 | MASH1 | bHLHa46achaete-scute complex homolog 1 (Drosophila)-HPRD,BioGRID10903890 
ASCL3HASH3 | SGN1 | bHLHa42achaete-scute complex homolog 3 (Drosophila)-HPRD11784080 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD,BioGRID10757985 
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)-HPRD10757985 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)-HPRD10757985 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD11713476|12861022 
Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex		BioGRID11713475 |11713476 
|12657632 |15331612 
HBP1FLJ16340HMG-box transcription factor 1-HPRD,BioGRID11500377 
ID1ID | bHLHb24inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinTwo-hybridBioGRID9242638 |9584154 
ID2GIG8 | ID2A | ID2H | MGC26389 | bHLHb26inhibitor of DNA binding 2, dominant negative helix-loop-helix protein-HPRD,BioGRID9242638 
ID3HEIR-1 | bHLHb25inhibitor of DNA binding 3, dominant negative helix-loop-helix protein-HPRD,BioGRID8999959 
LYL1bHLHa18lymphoblastic leukemia derived sequence 1Two-hybridBioGRID9242638 
MSCABF-1 | ABF1 | MYOR | bHLHa22musculin (activated B-cell factor-1)Two-hybridBioGRID9584154 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD,BioGRID8576241 |8999959 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)ETO interacts with E2-2.BIND15333839 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1Affinity Capture-MS
Reconstituted Complex
Two-hybrid		BioGRID8576241 |9242638 
|16407974 
TAL2bHLHa19T-cell acute lymphocytic leukemia 2Two-hybridBioGRID9242638 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD8999959 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4-HPRD,BioGRID8999959 |9668116 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_MYOGENESIS 2820All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_DN 2015All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_UP 116All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_DN 1511All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP 11271All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN 167100All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN 9557All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP 170114All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_DN 5733All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN 4533All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_DN 5935All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_DN 5132All SZGR genes in this pathway
PARK_HSC_MARKERS 4431All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
VICENT_METASTASIS_UP 1411All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN 159105All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_RECENT_THYMIC_EMIGRANT 227128All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP 6242All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_CNN1_DN 2018All SZGR genes in this pathway
KAMIKUBO_MYELOID_MN1_NETWORK 1914All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN 10367All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.