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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: THRB

Summary

GeneID

7068

Symbol

THRB

Synonyms

Description

thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

Locus tag

Gene type

protein-coding

Map location

3p24.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.006

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0385

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SATB2

0.83

0.81

NKAIN2

0.82

0.76

TDRD7

0.80

0.79

LPL

0.79

0.58

LGALS8

0.79

0.77

SLC44A5

0.79

0.66

CCBE1

0.79

0.62

ADAMTSL3

0.78

0.75

CHST15

0.77

0.79

RBM24

0.77

0.78

Top 10 negatively co-expressed genes

HSD17B14

-0.56

-0.61

MT-CO2

-0.53

AF347015.31

-0.52

-0.51

BDH2

-0.51

-0.55

MT-CYB

-0.51

-0.50

AF347015.8

-0.51

AIFM3

-0.51

-0.50

C11orf67

-0.51

-0.54

AF347015.27

-0.50

-0.49

AF347015.2

-0.50

-0.51

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004887

thyroid hormone receptor activity

TAS

1618799

GO:0003700

transcription factor activity

NAS

1618799

GO:0003707

steroid hormone receptor activity

IEA

GO:0003714

transcription corepressor activity

TAS

1618799

GO:0005515

protein binding

IPI

7870181 |15100213 |15625236

GO:0008270

zinc ion binding

IEA

GO:0046872

metal ion binding

IEA

GO:0043565

sequence-specific DNA binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0009887

organ morphogenesis

IEA

GO:0008016

regulation of heart contraction

IEA

GO:0007605

sensory perception of sound

IEA

GO:0016481

negative regulation of transcription

IEA

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

1618799

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANP32A	C15orf1 \| I1PP2A \| LANP \| MAPM \| MGC119787 \| MGC150373 \| PHAP1 \| PHAPI \| PP32	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	TR-beta interacts with pp32.	BIND	15308690
BRD8	SMAP \| SMAP2 \| p120	bromodomain containing 8	Reconstituted Complex Two-hybrid	BioGRID	9368056
BTG1	-	B-cell translocation gene 1, anti-proliferative	BTG1 interacts with THRB (TR-beta-1). This interaction was modeled on a demonstrated interaction between human BTG1 and TR-beta-1 from an unspecified species.	BIND	15674337
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	Affinity Capture-Western Reconstituted Complex	BioGRID	12048199
COPS2	ALIEN \| CSN2 \| SGN2 \| TRIP15	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	-	HPRD,BioGRID	7776974 \|10207062
CTCF	-	CCCTC-binding factor (zinc finger protein)	TR interacts with CTCF.	BIND	10625678
EIF3I	EIF3S2 \| PRO2242 \| TRIP-1 \| TRIP1 \| eIF3-beta \| eIF3-p36	eukaryotic translation initiation factor 3, subunit I	Two-hybrid	BioGRID	9368056
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	-	HPRD	10944117
JMJD1C	DKFZp761F0118 \| FLJ14374 \| KIAA1380 \| RP11-10C13.2 \| TRIP8	jumonji domain containing 1C	-	HPRD	7776974
MECR	CGI-63 \| FASN2B \| NRBF1	mitochondrial trans-2-enoyl-CoA reductase	-	HPRD	9795230
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	9325263
MED21	SRB7 \| SURB7	mediator complex subunit 21	TR-beta interacts with hSrb7.	BIND	15249124
MPG	AAG \| APNG \| CRA36.1 \| MDG \| Mid1 \| PIG11 \| PIG16 \| anpg	N-methylpurine-DNA glycosylase	MPG interacts with THRB (TR-beta). This interaction was modeled on a demonstrated interaction between MPG from an unspecified species and THRB from an unspecified species.	BIND	14761960
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	9171239
NCOA1		nuclear receptor coactivator 1	SRC-1 interacts with THR-beta. This interaction was modelled on a demonstrated interaction between human SRC-1 and rat TR-beta.	BIND	9346901
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	-	HPRD,BioGRID	11518802
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	GRIP1 interacts with TR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human TR.	BIND	10454563
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	TRAM-1 interacts with TR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and rat TR-beta.	BIND	9346901
NCOA3		nuclear receptor coactivator 3	ACTR interacts with TR.	BIND	9267036
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10823961 \|11158331 \|11773444
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	Reconstituted Complex	BioGRID	9751500
NR2F6	EAR-2 \| EAR2 \| ERBAL2	nuclear receptor subfamily 2, group F, member 6	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10713182
NRBF2	COPR1 \| COPR2 \| DKFZp564C1664 \| FLJ30395 \| NRBF-2	nuclear receptor binding factor 2	-	HPRD,BioGRID	10786636
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	-	HPRD,BioGRID	11751919
PPARGC1B	ERRL1 \| PERC \| PGC-1(beta) \| PGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	Reconstituted Complex	BioGRID	11733490
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	Reconstituted Complex	BioGRID	11050077
PRMT2	HRMT1L1 \| MGC111373	protein arginine methyltransferase 2	PRMT2 interacts with TR-beta.	BIND	12039952
PSMC3IP	GT198 \| HOP2 \| HUMGT198A \| TBPIP	PSMC3 interacting protein	-	HPRD	11739747
PSMC5	S8 \| SUG1 \| TBP10 \| TRIP1 \| p45 \| p45/SUG	proteasome (prosome, macropain) 26S subunit, ATPase, 5	Two-hybrid	BioGRID	7870181
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	Reconstituted Complex	BioGRID	9368056
RXRB	DAUDI6 \| H-2RIIBP \| MGC1831 \| NR2B2 \| RCoR-1	retinoid X receptor, beta	THR-beta interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between rat TR-beta and mouse RXR-beta.	BIND	9346901
RXRG	NR2B3 \| RXRC	retinoid X receptor, gamma	-	HPRD	9794455
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	10454579
TBL1X	EBI \| SMAP55 \| TBL1	transducin (beta)-like 1X-linked	Reconstituted Complex	BioGRID	10809664
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex	BioGRID	9751500
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	11258898
TRIP12	KIAA0045 \| MGC138849 \| MGC138850	thyroid hormone receptor interactor 12	-	HPRD	7776974
TRIP4	HsT17391	thyroid hormone receptor interactor 4	-	HPRD,BioGRID	7776974 \|10454579
TSG101	TSG10 \| VPS23	tumor susceptibility gene 101	Two-hybrid	BioGRID	10508170

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	272	195	All SZGR genes in this pathway
BIOCARTA_EGFR_SMRTE_PATHWAY	11	11	All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY	26	24	All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	352	181	All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	49	36	All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP	137	94	All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP	94	59	All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN	260	143	All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN	291	176	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN	150	93	All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_DN	65	45	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN	88	58	All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN	28	26	All SZGR genes in this pathway
CHENG_IMPRINTED_BY_ESTRADIOL	110	68	All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN	69	48	All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP	118	68	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP	344	215	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN	448	282	All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA	208	107	All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP	289	184	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	764	770	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	51	57	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	3770	3776	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	1472	1478	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124.1	1472	1478	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1472	1478	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1472	1478	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	3772	3778	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	3772	3778	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-135	1501	1508	1A,m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1501	1508	1A,m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	280	286	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-138	280	286	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	4447	4454	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	4447	4454	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-146	4321	4327	m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	4321	4327	m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-181	1410	1417	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-21	4632	4638	m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	4632	4638	m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-218	4167	4173	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-219	4108	4115	1A,m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-27	3772	3778	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	3772	3778	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-329	3813	3820	1A,m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-34b	1470	1476	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-381	4543	4549	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-431	4105	4111	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-452	4441	4448	1A,m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.