Gene Page: TJP1

Summary
GeneID  7082
Symbol  TJP1
Synonyms  DKFZp686M05161|MGC133289|ZO-1
Description  tight junction protein 1 (zona occludens 1)
See related  HGNC:11827|MIM:601009|Ensembl:ENSG00000104067|HPRD:03002|
Locus tag  -
Gene type  protein-coding
Map location  15q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MYLPF0.510.19
MXRA70.510.55
TESC0.500.68
SPOCK30.470.61
ACYP20.470.62
C9orf1030.470.53
CPLX10.460.60
FAM102A0.460.60
PNLDC10.450.57
HABP40.450.60
Top 10 negatively co-expressed genes
KIAA1211-0.41-0.45
AL033532.1-0.39-0.45
ST8SIA2-0.39-0.45
KIAA1949-0.38-0.50
SEMA4G-0.38-0.40
PNPLA3-0.38-0.44
GMIP-0.38-0.41
TTC28-0.38-0.38
GJC1-0.38-0.46
JUP-0.38-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI11042084 |12154091 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007043cell-cell junction assemblyTAS8486731 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIEABrain (GO term level: 10)-
GO:0005923tight junctionTASBrain (GO term level: 10)8486731 
GO:0005737cytoplasmIDA18029348 
GO:0005913cell-cell adherens junctionTAS8486731 
GO:0005886plasma membraneIDA18029348 
GO:0005886plasma membraneIEA-
GO:0016323basolateral plasma membraneIDA16427635 
GO:0030054cell junctionIDA18029348 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CGNDKFZp779N1112 | FLJ39281 | KIAA1319cingulin-HPRD,BioGRID10613913 |12023291|11042084 
-HPRD11042084 
Cingulin interacts with ZO-1.BIND10613913 
CLDN1CLD1 | ILVASC | SEMP1claudin 1-HPRD,BioGRID10601346 
CLDN2-claudin 2-HPRD,BioGRID10601346 
CLDN3C7orf1 | CPE-R2 | CPETR2 | HRVP1 | RVP1claudin 3-HPRD,BioGRID10601346 
CLDN4CPE-R | CPER | CPETR | CPETR1 | WBSCR8 | hCPE-Rclaudin 4-HPRD,BioGRID10601346 
CLDN5AWAL | BEC1 | CPETRL1 | TMVCFclaudin 5-HPRD,BioGRID10601346 
CLDN6-claudin 6Reconstituted ComplexBioGRID10601346 
CLDN7CEPTRL2 | CPETRL2 | Hs.84359 | claudin-1claudin 7-HPRD,BioGRID10601346 
CLDN8-claudin 8-HPRD,BioGRID10601346 
CTTNEMS1 | FLJ34459cortactin-HPRD9792678|11018051 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID12708492 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10856295 |12953056 
GJA1CX43 | DFNB38 | GJAL | ODDDgap junction protein, alpha 1, 43kDa-HPRD,BioGRID9707407 
GJA3CX46 | CZP3gap junction protein, alpha 3, 46kDa-HPRD,BioGRID12808044 
GJA8CAE | CAE1 | CX50 | CZP1 | MP70gap junction protein, alpha 8, 50kDa-HPRD,BioGRID12808044 
GJB3CX31 | DFNA2 | EKV | FLJ22486 | MGC102938gap junction protein, beta 3, 31kDa-HPRD12154091 
GJC1CX45 | DKFZp686P0738 | GJA7gap junction protein, gamma 1, 45kDa-HPRD11557048 |12064590|12064590 
-HPRD,BioGRID12064590 
GJD3CX31.9 | Cx30.2 | GJA11 | GJC1gap junction protein, delta 3, 31.9kDaAffinity Capture-Western
Reconstituted Complex		BioGRID12154091 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GRIN2DEB11 | NMDAR2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D-HPRD10862698 
JAM2C21orf43 | CD322 | JAM-B | JAMB | PRO245 | VE-JAM | VEJAMjunctional adhesion molecule 2-HPRD,BioGRID12953056 
JAM3FLJ14529 | JAM-C | JAMCjunctional adhesion molecule 3-HPRD,BioGRID12953056 
KIRRELFLJ10845 | MGC129542 | MGC129543 | NEPH1kin of IRRE like (Drosophila)-HPRD,BioGRID12578837 |12865409 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD,BioGRID10334923 
NPHS1CNF | NPHNnephrosis 1, congenital, Finnish type (nephrin)Reconstituted ComplexBioGRID15331416 
OCLN-occludinAffinity Capture-Western
Reconstituted Complex		BioGRID9792688 |12169098 
-HPRD7798316 |9792688 
|10575001 |10601346 
|11700038 |12169098 
PTPN14MGC126803 | PEZ | PTP36protein tyrosine phosphatase, non-receptor type 14-HPRD,BioGRID12808048 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)Affinity Capture-Western
Reconstituted Complex		BioGRID9792688 |10026224 
|10575001 
-HPRD7542259 
TJP3MGC119546 | ZO-3tight junction protein 3 (zona occludens 3)Affinity Capture-WesternBioGRID10575001 
-HPRD9531559 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_VIBRIO_CHOLERAE_INFECTION 5632All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 6844All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY 3124All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_SIGNALING_BY_HIPPO 2215All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 126All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN 167100All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_240_MCF10A 5736All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C2 5439All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
KANG_DOXORUBICIN_RESISTANCE_DN 198All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
NADELLA_PRKAR1A_TARGETS_UP 95All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
BAE_BRCA1_TARGETS_DN 3227All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1017417471Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/107117811841Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-137109611021Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-3p134513511Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1447407471A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-18510561062m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-1912973041A,m8hsa-miR-191brainCAACGGAAUCCCAAAAGCAGCU
miR-1933133191Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-194116311691Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-330242248m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-335106810741Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-45513101316m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-493-5p488494m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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