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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: TNFRSF1A

Summary

GeneID

7132

Symbol

TNFRSF1A

Synonyms

CD120a|FPF|MGC19588|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR55|TNFR60|p55|p55-R|p60

Description

tumor necrosis factor receptor superfamily, member 1A

Locus tag

Gene type

protein-coding

Map location

12p13.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0126

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PCM1

0.95

0.96

PHF3

0.94

0.96

SLTM

0.94

0.95

TAF1

0.94

0.95

CHD2

0.93

0.95

ZNF638

0.93

0.95

RFC1

0.93

CASP8AP2

0.92

0.94

SETD2

0.92

0.96

ZC3H11A

0.92

0.95

Top 10 negatively co-expressed genes

AF347015.31

-0.76

-0.85

MT-CO2

-0.74

-0.83

IFI27

-0.74

-0.82

AF347015.27

-0.73

-0.80

FXYD1

-0.72

-0.80

HIGD1B

-0.72

-0.83

AF347015.21

-0.71

-0.85

AF347015.33

-0.71

-0.78

ENHO

-0.71

-0.82

MYL3

-0.70

-0.81

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IEA

GO:0005031

tumor necrosis factor receptor activity

TAS

2158863

GO:0005515

protein binding

IPI

9115275 |11684708 |15465831

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006693

prostaglandin metabolic process

ISS

GO:0006915

apoptosis

IEA

GO:0019221

cytokine-mediated signaling pathway

ISS

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

IEP

12761501

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

ISS

GO:0050729

positive regulation of inflammatory response

ISS

GO:0044419

interspecies interaction between organisms

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005576

extracellular region

NAS

12189246

GO:0005886

plasma membrane

EXP

2848815 |7758105 |12887920

GO:0005886

plasma membrane

IEA

GO:0005887

integral to plasma membrane

TAS

1698610

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Co-purification	BioGRID	15659383
ATAD3A	FLJ10709	ATPase family, AAA domain containing 3A	-	HPRD	14743216
ATP1A1	MGC3285 \| MGC51750	ATPase, Na+/K+ transporting, alpha 1 polypeptide	-	HPRD	14743216
ATP2A2	ATP2B \| DAR \| DD \| DKFZp686P0211 \| FLJ20293 \| FLJ38063 \| MGC45367 \| SERCA2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	-	HPRD	14743216
ATP5A1	ATP5A \| ATP5AL2 \| ATPM \| MOM2 \| OMR \| ORM \| hATP1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	-	HPRD	14743216
BAG4	BAG-4 \| SODD	BCL2-associated athanogene 4	-	HPRD,BioGRID	9915703
BCL10	CARMEN \| CIPER \| CLAP \| c-E10 \| mE10	B-cell CLL/lymphoma 10	Two-hybrid	BioGRID	10400625
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Co-purification	BioGRID	15659383
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	Affinity Capture-Western	BioGRID	8943045
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	-	HPRD	11098060
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Affinity Capture-Western Co-purification	BioGRID	9045686 \|15659383
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	Affinity Capture-Western	BioGRID	8985253
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11755217
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Co-purification	BioGRID	15659383
CDIPT	MGC1328 \| PIS \| PIS1	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	-	HPRD	14743216
CEP110	CEP1 \| FAN \| bA165P4.1	centrosomal protein 110kDa	Affinity Capture-Western	BioGRID	10187805
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD	10755617
CRADD	MGC9163 \| RAIDD	CASP2 and RIPK1 domain containing adaptor with death domain	Affinity Capture-Western	BioGRID	8985253
DAP	MGC99796	death-associated protein	-	HPRD	10187798
DAPK1	DAPK \| DKFZp781I035	death-associated protein kinase 1	-	HPRD,BioGRID	12911633
ERAP1	A-LAP \| ALAP \| APPILS \| ARTS-1 \| ARTS1 \| ERAAP \| ERAAP1 \| KIAA0525 \| PILS-AP \| PILSAP	endoplasmic reticulum aminopeptidase 1	ARTS-1 interacts with TNFR1.	BIND	12189246
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	Co-purification	BioGRID	15659383
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	Affinity Capture-Western Co-purification	BioGRID	8565075 \|15659383
FANCD2	DKFZp762A223 \| FA-D2 \| FA4 \| FACD \| FAD \| FAD2 \| FANCD \| FLJ23826	Fanconi anemia, complementation group D2	Affinity Capture-MS	BioGRID	14743216
FANCI	FLJ10719 \| KIAA1794	Fanconi anemia, complementation group I	-	HPRD	14743216
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	Co-purification	BioGRID	15659383
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	Co-purification	BioGRID	15659383
GCN1L1	GCN1 \| GCN1L \| KIAA0219	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	-	HPRD	14743216
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	TNF-R55 interacts with RACK1.	BIND	12391233
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1		-	HPRD	12391233
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	10359574
HAX1	FLJ17042 \| FLJ18492 \| FLJ93803 \| HCLSBP1 \| HS1BP1 \| SCN3	HCLS1 associated protein X-1	-	HPRD	14743216
HIST2H4A	FO108 \| H4 \| H4/n \| H4F2 \| H4FN \| HIST2H4	histone cluster 2, H4a	-	HPRD	14743216
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	7876093
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD,BioGRID	11909948
HSPA8		heat shock 70kDa protein 8	-	HPRD	11909948\|14743216
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD,BioGRID	10755617
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD,BioGRID	10755617
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	11801527
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	9510175
LRRC59	FLJ21675 \| PRO1855	leucine rich repeat containing 59	-	HPRD	14743216
LTA	LT \| TNFB \| TNFSF1	lymphotoxin alpha (TNF superfamily, member 1)	-	HPRD,BioGRID	8387891
LTB	TNFC \| TNFSF3 \| p33	lymphotoxin beta (TNF superfamily, member 3)	-	HPRD,BioGRID	7995952
MADD	DENN \| FLJ35600 \| FLJ36300 \| IG20 \| KIAA0358 \| RAB3GEP	MAP-kinase activating death domain	-	HPRD,BioGRID	9115275
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Co-purification	BioGRID	15659383
MOAP1	MAP-1 \| PNMA4	modulator of apoptosis 1	TNF-R1 interacts with MAP-1.	BIND	15949439
MON2	KIAA1040 \| MGC35493	MON2 homolog (S. cerevisiae)	-	HPRD	14743216
MRCL3	MLCB \| MRLC3	myosin regulatory light chain MRCL3	-	HPRD	14743216
MSN	-	moesin	Co-purification	BioGRID	15659383
MYL6	ESMLC \| LC17-GI \| LC17-NM \| LC17A \| LC17B \| MLC1SM \| MLC3NM \| MLC3SM	myosin, light chain 6, alkali, smooth muscle and non-muscle	-	HPRD	14743216
NOL3	ARC \| CARD2 \| MYC \| MYP \| NOP \| NOP30	nucleolar protein 3 (apoptosis repressor with CARD domain)	Phenotypic Suppression	BioGRID	9560245
NSMAF	FAN	neutral sphingomyelinase (N-SMase) activation associated factor	-	HPRD,BioGRID	8808629
NSMAF	FAN		TNF-R55 interacts with FAN.	BIND	12391233
PIP4K2B	PI5P4KB \| PIP5K2B \| PIP5KIIB \| PIP5KIIbeta	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	-	HPRD,BioGRID	9038203 \|9753329
PSMD2	MGC14274 \| P97 \| Rpn1 \| S2 \| TRAP2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	-	HPRD,BioGRID	7601280 \|9126987
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD	11786908
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	-	HPRD	11786908
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	TNFR1 interacts with RIP1.	BIND	15247912
RASSF1	123F2 \| NORE2A \| RASSF1A \| RDA32 \| REH3P21	Ras association (RalGDS/AF-6) domain family member 1	TNF-R1 interacts with RASSF1A.	BIND	15949439
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	Co-purification	BioGRID	15659383
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD,BioGRID	8612133
RIPK2	CARD3 \| CARDIAK \| CCK \| GIG30 \| RICK \| RIP2	receptor-interacting serine-threonine kinase 2	-	HPRD,BioGRID	9642260
RIPK3	RIP3	receptor-interacting serine-threonine kinase 3	-	HPRD,BioGRID	10339433
RPS3	FLJ26283 \| FLJ27450 \| MGC87870	ribosomal protein S3	-	HPRD	14743216
SEC61A1	HSEC61 \| SEC61 \| SEC61A	Sec61 alpha 1 subunit (S. cerevisiae)	-	HPRD	14743216
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	10848577
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	Reconstituted Complex Two-hybrid	BioGRID	8906799 \|10187798
TNF	DIF \| TNF-alpha \| TNFA \| TNFSF2	tumor necrosis factor (TNF superfamily, member 2)	-	HPRD	1331108 \|2158863
			Affinity Capture-MS Affinity Capture-Western	BioGRID	12887920 \|14743216
			TNF-alpha interacts with TNFR1.	BIND	7852363
TNFRSF10B	CD262 \| DR5 \| KILLER \| KILLER/DR5 \| TRAIL-R2 \| TRAILR2 \| TRICK2 \| TRICK2A \| TRICK2B \| TRICKB \| ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	Co-purification	BioGRID	15659383
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	-	HPRD	8077196\|10875917
			Affinity Capture-Western FRET Two-hybrid	BioGRID	8077196 \|10875917
			TNFR1 interacts with itself.	BIND	8077196
TNFSF12-TNFSF13	TWE-PRIL	TNFSF12-TNFSF13 readthrough transcript	-	HPRD	10706119
TNFSF13	APRIL \| CD256 \| TALL2 \| TRDL-1 \| UNQ383/PRO715 \| ligand	tumor necrosis factor (ligand) superfamily, member 13	Reconstituted Complex	BioGRID	10706119
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	Affinity Capture-Western Two-hybrid	BioGRID	8565075 \|8612133 \|8943045 \|9082980 \|9915703 \|10187805
			-	HPRD	8565075 \|8612133 \|10911999\|8612133 \|10911999
			TRADD interacts with TNFR1.	BIND	11684708
			-	HPRD	8612133 \|10911999
			TNFR1 interacts with TRADD. This interaction was modeled on a demonstrated interaction between TNFR1 from an unspecified species and human TRADD.	BIND	11226577
			TNFR1 interacts with TRADD.	BIND	15247912
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD,BioGRID	8565075
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD,BioGRID	8565075
TRAP1	HSP75 \| HSP90L	TNF receptor-associated protein 1	Reconstituted Complex	BioGRID	7876093
TRPC4AP	C20orf188 \| TRRP4AP \| TRUSS	transient receptor potential cation channel, subfamily C, member 4 associated protein	Affinity Capture-Western Reconstituted Complex	BioGRID	14585990
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14743216
TUBB2B	DKFZp566F223 \| FLJ98847 \| MGC8685 \| TUBB-PARALOG \| bA506K6.1	tubulin, beta 2B	-	HPRD	14743216
TUBB6	HsT1601 \| MGC132410 \| MGC4083 \| TUBB-5	tubulin, beta 6	-	HPRD	14743216
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD,BioGRID	9563508

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-29	117	124	1A,m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.