Gene Page: TSHR

Summary
GeneID  7253
Symbol  TSHR
Synonyms  CHNG1|LGR3|MGC75129|hTSHR-I
Description  thyroid stimulating hormone receptor
See related  HGNC:12373|MIM:603372|Ensembl:ENSG00000165409|HPRD:04537|
Locus tag  -
Gene type  protein-coding
Map location  14q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0146 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GSPT10.950.95
DIS30.940.94
C17orf710.940.94
FAM172A0.930.95
DCTN40.930.95
VEZT0.930.95
ZMYM40.930.96
MARCH50.930.94
WDR480.930.94
KPNA30.930.94
Top 10 negatively co-expressed genes
FXYD1-0.77-0.87
MT-CO2-0.75-0.85
AF347015.31-0.74-0.83
AF347015.33-0.74-0.83
IFI27-0.73-0.83
AF347015.8-0.72-0.83
AF347015.27-0.71-0.81
HIGD1B-0.71-0.83
MT-CYB-0.71-0.81
AC021016.1-0.71-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004996thyroid-stimulating hormone receptor activityIEA-
GO:0004996thyroid-stimulating hormone receptor activityTAS8552586 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerTAS8552586 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007267cell-cell signalingTAS7920658 
GO:0007165signal transductionIEA-
GO:0008284positive regulation of cell proliferationTAS7920658 
GO:0008344adult locomotory behaviorIEA-
GO:0040012regulation of locomotionIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0030183B cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8552586 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALCRCRT | CTR | CTR1calcitonin receptorAffinity Capture-WesternBioGRID12383251 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulin-HPRD12383251 
TSHR interacts with the molecular chaperone protein calreticulin. This interaction was modeled on a demonstrated interaction between human TSHR and rabbit calreticulin.BIND12383251 
CANXCNX | FLJ26570 | IP90 | P90calnexinThyroid-Stimulating Hormone Receptor interacts with the molecular chaperone calnexin. This interaction was modeled on a demonstrated interaction between human TSHR and dog calnexin.BIND12383251 
-HPRD,BioGRID12383251 
FLNBABP-278 | AOI | DKFZp686A1668 | DKFZp686O033 | FH1 | FLN1L | LRS1 | SCT | TABP | TAPfilamin B, beta (actin binding protein 278)-HPRD,BioGRID8327473 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD,BioGRID11981027 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12-HPRD8552586 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13-HPRD8552586 
GNAQG-ALPHA-q | GAQguanine nucleotide binding protein (G protein), q polypeptide-HPRD8188646 
GNASAHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | MGC33735 | PHP1A | PHP1B | POH | dJ309F20.1.1 | dJ806M20.3.3GNAS complex locus-HPRD9525885 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)TSHR interacts with BiP. This interaction was modeled on a demonstrated interaction between human TSHR and hamster BiP.BIND12383251 
-HPRD,BioGRID12383251 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID10809230 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID10809230 
LHCGRFLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-Rluteinizing hormone/choriogonadotropin receptor-HPRD1651314 
SCRIBCRIB1 | SCRB1 | SCRIB1 | Vartulscribbled homolog (Drosophila)TSHR interacts with an unspecified isoform of SCRIB.BIND15775968 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID10809230 
TSHBCHNG4 | TSH-BETAthyroid stimulating hormone, beta-HPRD2558651 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptorTSHr homodimerizes.BIND15889138 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS 108All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_DN 5735All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN 5233All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_DN 10567All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53 10963All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_UP 10759All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_UP 3623All SZGR genes in this pathway


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