Gene Page: UBB

Summary
GeneID  7314
Symbol  UBB
Synonyms  FLJ25987|MGC8385
Description  ubiquitin B
See related  HGNC:12463|MIM:191339|Ensembl:ENSG00000170315|HPRD:06771|
Locus tag  -
Gene type  protein-coding
Map location  17p12-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1312 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA14680.940.94
SHOC20.930.93
SCAMP10.930.95
AVL90.920.94
LRPPRC0.920.92
PAFAH1B10.920.93
UBQLN10.920.91
MTMR90.920.94
RANBP60.910.93
SLC25A460.910.92
Top 10 negatively co-expressed genes
FXYD1-0.72-0.72
MT-CO2-0.72-0.72
AF347015.31-0.71-0.72
HIGD1B-0.70-0.72
AF347015.8-0.70-0.72
AF347015.2-0.69-0.68
AF347015.33-0.69-0.68
MT-CYB-0.69-0.69
AF347015.21-0.69-0.70
SLC25A18-0.67-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI14528304 
GO:0030528transcription regulator activityIDA14528304 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceTASaxon (GO term level: 13)12367500 
GO:0048167regulation of synaptic plasticityTASSynap (GO term level: 8)12367500 
GO:0042062long-term strengthening of neuromuscular junctionTASSynap (GO term level: 13)12367500 
GO:0006464protein modification processIEA-
GO:0007049cell cycleTAS12367500 
GO:0016567protein ubiquitinationIDA14528304 
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processEXP11285280 
GO:0030433ER-associated protein catabolic processTAS11597332 
GO:0045941positive regulation of transcriptionIDA14528304 
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP15029244 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9660940 |10995389 |11285280 
|11742988 |11931757 
|12070128 |12218189 
|12593796 |12820959 
|15469984 |15781449 
|16 
GO:0005634nucleusIC14528304 
GO:0005654nucleoplasmEXP11231585 |11931757 |15029244 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with Ub. This interaction was modelled on a demonstrated interaction between human BRCA1 and Ub from an unspecified source.BIND11320250 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)Ub interacts with p27.BIND15469821 
DAZAP2KIAA0058 | MGC14319 | MGC766 | PRTBDAZ associated protein 2Two-hybridBioGRID16189514 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaUb ubiquitinates NEMO.BIND14695475 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologLyn interacts with ubiquitin.BIND11046148 
MALT1DKFZp434L132 | MLT | MLT1mucosa associated lymphoid tissue lymphoma translocation gene 1Ub ubiquitinates paracaspase.BIND14695475 
MYBL2B-MYB | BMYB | MGC15600v-myb myeloblastosis viral oncogene homolog (avian)-like 2-HPRD,BioGRID10871850 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkinParkin is S-nitrosylated.BIND15105460 
SNCAIPMGC39814 | SYPH1synuclein, alpha interacting proteinSynphilin-1 is ubiquitinated.BIND15105460 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseSyk interacts with ubiquitin.BIND11046148 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6TRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source.BIND15125833 
USP1UBPubiquitin specific peptidase 1USP1 interacts with Ubiquitin.BIND15694335 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-5431151211Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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