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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: UBE2L3

Summary

GeneID

7332

Symbol

UBE2L3

Synonyms

E2-F1|L-UBC|UBCH7|UbcM4

Description

ubiquitin-conjugating enzyme E2L 3

Locus tag

Gene type

protein-coding

Map location

22q11.21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

FBXO38

0.90

0.89

DHX8

0.90

NAT10

0.90

0.89

DDB1

0.89

BRAP

0.89

0.88

ASB8

0.89

0.88

ZNF207

0.89

0.88

BRD8

0.88

0.89

EXT2

0.88

0.90

PSMD11

0.88

Top 10 negatively co-expressed genes

AF347015.21

-0.79

-0.84

MT-CO2

-0.78

-0.81

AF347015.31

-0.78

-0.81

IFI27

-0.76

-0.81

AF347015.8

-0.74

-0.79

AF347015.27

-0.74

-0.79

AF347015.33

-0.74

-0.77

HIGD1B

-0.73

-0.79

MT-CYB

-0.73

-0.76

FXYD1

-0.73

-0.79

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004842

ubiquitin-protein ligase activity

TAS

8563171 |8576257

GO:0016874

ligase activity

IEA

GO:0019787

small conjugating protein ligase activity

IEA

GO:0019899

enzyme binding

TAS

8563171

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006511

ubiquitin-dependent protein catabolic process

TAS

8563171 |8672131

GO:0051246

regulation of protein metabolic process

IEA

GO:0043687

post-translational protein modification

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000151

ubiquitin ligase complex

TAS

8563171

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARIH1	ARI \| DKFZp686O13120 \| FLJ20329 \| FLJ93118 \| HARI \| HHARI \| UBCH7BP	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	An unspecified isoform of UbcH7 interacts with Ari-1. This interaction was modeled on a demonstrated interaction between human UbcH7 and Drosophila melanogaster Ari-1.	BIND	12234920
ARIH1			-	HPRD,BioGRID	10521492 \|11278816
ARIH2	ARI2 \| FLJ10938 \| FLJ33921 \| TRIAD1	ariadne homolog 2 (Drosophila)	Two-hybrid	BioGRID	16169070
ARIH2	ARI2 \| FLJ10938 \| FLJ33921 \| TRIAD1	ariadne homolog 2 (Drosophila)	An unspecified isoform of UbcH7 interacts with hAri-2.	BIND	12234920
AURKA	AIK \| ARK1 \| AURA \| AURORA2 \| BTAK \| MGC34538 \| STK15 \| STK6 \| STK7	aurora kinase A	Affinity Capture-MS	BioGRID	17353931
BARD1	-	BRCA1 associated RING domain 1	-	HPRD	12732733
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	12732733
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Affinity Capture-Western Co-crystal Structure Reconstituted Complex	BioGRID	10531381 \|10966114 \|12234920
			-	HPRD	10531381 \|10966114 \|11278816
			c-Cbl interacts with an unspecified isoform of UbcH7. This interaction was modeled on a demonstrated interaction between c-Cbl from an unspecified species and human UbcH7.	BIND	12234920
EIF4E2	4E-LP \| 4EHP \| EIF4EL3 \| IF4e	eukaryotic translation initiation factor 4E family member 2	Affinity Capture-Western	BioGRID	14623119
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	9990509
NEDD4L	FLJ33870 \| KIAA0439 \| NEDD4-2 \| RSP5 \| hNedd4-2	neural precursor cell expressed, developmentally down-regulated 4-like	-	HPRD	8576257
PARC	DKFZp686G1042 \| DKFZp686P2024 \| H7AP1 \| RP3-330M21.2	p53-associated parkin-like cytoplasmic protein	-	HPRD,BioGRID	10521492
PARK2	AR-JP \| LPRS2 \| PDJ \| PRKN	Parkinson disease (autosomal recessive, juvenile) 2, parkin	-	HPRD,BioGRID	11078524 \|11278816
PTEN	10q23del \| BZS \| MGC11227 \| MHAM \| MMAC1 \| PTEN1 \| TEP1	phosphatase and tensin homolog	-	HPRD,BioGRID	12620973
RNF144A	KIAA0161 \| RNF144 \| UBCE7IP4	ring finger protein 144A	-	HPRD	10431818
RNF19A	DKFZp566B1346 \| DORFIN \| RNF19	ring finger protein 19A	-	HPRD,BioGRID	11237715
RNF216	TRIAD3 \| U7I1 \| UBCE7IP1 \| ZIN	ring finger protein 216	-	HPRD,BioGRID	15107846
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	-	HPRD	12794086
UBE3A	ANCR \| AS \| E6-AP \| EPVE6AP \| FLJ26981 \| HPVE6A	ubiquitin protein ligase E3A	UbcH7 interacts with E6AP.	BIND	9153201
			Biochemical Activity Co-crystal Structure	BioGRID	8576257 \|9990509 \|10558980
			-	HPRD	8576257 \|10558980
UBOX5	KIAA0860 \| RNF37 \| UBCE7IP5 \| UIP5	U-box domain containing 5	-	HPRD,BioGRID	11274149

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	1982	1989	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1982	1989	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-182	1796	1802	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-26	1173	1179	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1173	1179	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-370	69	75	1A	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-377	784	790	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-409-5p	164	170	m8	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-544	1743	1749	1A	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-96	1796	1802	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.