Gene Page: VCL

Summary
GeneID  7414
Symbol  VCL
Synonyms  CMD1W|MVCL
Description  vinculin
See related  HGNC:12665|MIM:193065|Ensembl:ENSG00000035403|HPRD:01900|
Locus tag  RP11-178G16.3
Gene type  protein-coding
Map location  10q22.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.169 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIDA7816144 
GO:0005198structural molecule activityIEA-
GO:0016491oxidoreductase activityISS-
GO:0045294alpha-catenin bindingIPI9700171 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS15501673 
GO:0006928cell motionTAS16130169 
GO:0030336negative regulation of cell migrationTAS15494027 
GO:0043297apical junction assemblyIMP9700171 
GO:0030032lamellipodium biogenesisISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionISS-
GO:0005916fascia adherensIEA-
GO:0005912adherens junctionISS-
GO:0005911cell-cell junctionISS-
GO:0005886plasma membraneIEA-
GO:0015629actin cytoskeletonIEA-
GO:0030055cell-substrate junctionNAS2116004 
GO:0043234protein complexIDA9700171 
GO:0043034costamereISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI2ABI-2 | ABI2B | AIP-1 | AblBP3 | SSH3BP2 | argBPIA | argBPIBabl interactor 2Two-hybridBioGRID16189514 
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscle-HPRD7816144 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1Affinity Capture-WesternBioGRID11577104 
C19orf57MGC11271 | MGC149720chromosome 19 open reading frame 57Two-hybridBioGRID16189514 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-WesternBioGRID9405455 |9535896 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD,BioGRID8276759 
CORO2BCLIPINC | KIAA0925coronin, actin binding protein, 2B-HPRD,BioGRID10224093 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD,BioGRID9700171 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID9405455 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD,BioGRID11577104 
NRAP-nebulin-related anchoring protein-HPRD,BioGRID10320340 
PSME1IFI5111 | MGC8628 | PA28A | PA28alpha | REGalphaproteasome (prosome, macropain) activator subunit 1 (PA28 alpha)Two-hybridBioGRID16169070 
PXNFLJ16691paxillin-HPRD,BioGRID9054445 
-HPRD7525621 |7534286|9054445 
RAVER1KIAA1978ribonucleoprotein, PTB-binding 1-HPRD11724819 
SELECD62E | ELAM | ELAM1 | ESEL | LECAM2selectin E-HPRD8609175 
SORBS1CAP | DKFZp451C066 | DKFZp586P1422 | FLAF2 | FLJ12406 | KIAA1296 | R85FL | SH3D5 | SH3P12 | SORB1sorbin and SH3 domain containing 1-HPRD,BioGRID10085297 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2-HPRD,BioGRID10521485 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1Reconstituted ComplexBioGRID9858471 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6Two-hybridBioGRID16189514 
VASP-vasodilator-stimulated phosphoprotein-HPRD,BioGRID10882740 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_CELL2CELL_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_MUSCLE_CONTRACTION 4824All SZGR genes in this pathway
REACTOME_SMOOTH_MUSCLE_CONTRACTION 2514All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
TOMLINS_PROSTATE_CANCER_DN 4033All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
GUENTHER_GROWTH_SPHERICAL_VS_ADHERENT_DN 2619All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
LU_IL4_SIGNALING 9456All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_CHROMOSOME_12_TRISOMY 2412All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_UP 4836All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
BURTON_ADIPOGENESIS_10 3017All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
WU_HBX_TARGETS_3_UP 1811All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP 10369All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8 8657All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_DN 4429All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN 2818All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_DN 4031All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
ZHAN_EARLY_DIFFERENTIATION_GENES_DN 4229All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
VALK_AML_CLUSTER_12 3020All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_UP 6141All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
CHEMELLO_SOLEUS_VS_EDL_MYOFIBERS_DN 1910All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1079549611A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-182167816841Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-29792798m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-34/449882888m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-485-3p166716731Ahsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-9168016861Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96167816841Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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