Gene Page: WRN

Summary
GeneID  7486
Symbol  WRN
Synonyms  DKFZp686C2056|RECQ3|RECQL2|RECQL3
Description  Werner syndrome
See related  HGNC:12791|MIM:604611|Ensembl:ENSG00000165392|HPRD:05212|
Locus tag  -
Gene type  protein-coding
Map location  8p12-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RAB6A0.930.91
ITFG10.920.92
ARMCX30.920.90
CLTC0.920.93
C5orf220.910.92
USP140.910.89
VPS410.910.88
PNMA20.910.89
SRPK20.910.91
NCKAP10.900.90
Top 10 negatively co-expressed genes
AF347015.21-0.65-0.52
AF347015.2-0.65-0.53
MT-CO2-0.64-0.54
EIF4EBP3-0.63-0.65
AF347015.8-0.63-0.53
HIGD1B-0.63-0.54
FXYD1-0.62-0.55
AF347015.31-0.61-0.53
AF347015.26-0.61-0.49
MT-CYB-0.60-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000403Y-form DNA bindingIDA17715146 
GO:0000405bubble DNA bindingIDA11433031 
GO:0003677DNA bindingIDA9288107 
GO:0004003ATP-dependent DNA helicase activityIDA9288107 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:00084083'-5' exonuclease activityIDA10783163 |12181313 
GO:0009378four-way junction helicase activityIDA11433031 
GO:0016887ATPase activityIDA10373438 |10871376 
GO:0042803protein homodimerization activityIDA10783163 
GO:0032403protein complex bindingIDA10783163 
GO:00431383'-5' DNA helicase activityIDA17715146 
GO:0051880G-quadruplex DNA bindingIDA11433031 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000723telomere maintenanceIMP18212065 
GO:0000731DNA synthesis during DNA repairIDA17563354 
GO:0001302replicative cell agingIEA-
GO:0006310DNA recombinationIEA-
GO:0006284base-excision repairIDA17611195 
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processIEA-
GO:0010225response to UV-CIDA17563354 
GO:0010259multicellular organismal agingIMP16673358 
GO:0006979response to oxidative stressIDA17611195 
GO:0042981regulation of apoptosisIGI9681877 
GO:0051345positive regulation of hydrolase activityIDA17611195 
GO:0031297replication fork processingIDA17115688 
GO:0031297replication fork processingIMP12882351 
GO:0040009regulation of growth rateIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA17498979 
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005654nucleoplasmIDA11420665 |12944467 
GO:0005730nucleolusIDA9618508 |12181313 
GO:0032389MutLalpha complexIDA17715146 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedProtein-peptideBioGRID10608806 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeBLM interacts with WRN.BIND11919194 
-HPRD,BioGRID11919194 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)p14 interacts with WRN.BIND15355988 
FEN1FEN-1 | MF1 | RAD2flap structure-specific endonuclease 1-HPRD12356323 
Affinity Capture-Western
Reconstituted Complex		BioGRID11598021 |14688284 
MDC1DKFZp781A0122 | KIAA0170 | MGC166888 | NFBD1mediator of DNA damage checkpoint 1Protein-peptideBioGRID14578343 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1WRN interacts with PARP1.BIND14734561 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID10871373 |12633936 
POLR1CRPA39 | RPA40 | RPA5 | RPAC1polymerase (RNA) I polypeptide C, 30kDa-HPRD,BioGRID11971179 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptide-HPRD,BioGRID11889123 
RAD52-RAD52 homolog (S. cerevisiae)WRN interacts with RAD52.BIND12750383 
RDM1MGC33977 | RAD52BRAD52 motif 1-HPRD12750383 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2-HPRD,BioGRID12181313 
Wrn interacts with TRF2.BIND12181313 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53WRN interacts with p53.BIND12080066 
-HPRD,BioGRID11427532 |12080066 
WRNIP1FLJ22526 | RP11-420G6.2 | WHIP | bA420G6.2Werner helicase interacting protein 1-HPRD,BioGRID11301316 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)-HPRD,BioGRID12177300 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6WRN interacts with G22P1 (Ku70) as part of a complex.BIND14734561 
-HPRD,BioGRID12177300 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
MARKS_ACETYLATED_NON_HISTONE_PROTEINS 159All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_9 86All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
COLLIS_PRKDC_SUBSTRATES 2015All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN 6447All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_DN 7945All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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