Gene Page: YWHAE

Summary
GeneID  7531
Symbol  YWHAE
Synonyms  14-3-3E|FLJ45465|KCIP-1|MDCR|MDS
Description  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
See related  HGNC:12851|MIM:605066|Ensembl:ENSG00000108953|HPRD:05457|
Locus tag  -
Gene type  protein-coding
Map location  17p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.539 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF1310.940.95
DDX200.920.93
ZNF6150.920.93
ZNF280D0.920.93
ZNF5670.910.92
TOPORS0.910.92
WDR430.910.92
PHF20L10.910.92
ZNF1750.910.91
C10orf1370.910.93
Top 10 negatively co-expressed genes
MT-CO2-0.77-0.86
AF347015.31-0.77-0.85
FXYD1-0.76-0.86
AF347015.33-0.75-0.83
AF347015.27-0.75-0.84
IFI27-0.75-0.85
MT-CYB-0.74-0.83
AF347015.8-0.74-0.85
HIGD1B-0.74-0.86
AIFM3-0.73-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0019904protein domain specific bindingIEA-
GO:0019899enzyme bindingIPI10788521 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007242intracellular signaling cascadeTAS7644510 
GO:0006605protein targetingIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF2DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40rho/rac guanine nucleotide exchange factor (GEF) 2-HPRD14970201 
BADBBC2 | BCL2L8BCL2-associated agonist of cell death-HPRD,BioGRID9369453 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3The cIAP-2 promoter interacts with 14-3-3-epsilon.BIND15494311 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD10088721 
CDC25ACDC25A2cell division cycle 25 homolog A (S. pombe)-HPRD,BioGRID7644510 
-HPRD7644510 |14559997 
14-3-3-epsilon interacts with cdc25A.BIND7644510 
CDC25B-cell division cycle 25 homolog B (S. pombe)-HPRD,BioGRID7644510 |10713667 
14-3-3-epsilon interacts with cdc25B.BIND7644510 
CDC25CCDC25cell division cycle 25 homolog C (S. pombe)Affinity Capture-WesternBioGRID10330186 
CDC2L1CDC2L2 | CDK11 | CDK11-p110 | CDK11-p46 | CDK11-p58 | CLK-1 | FLJ59152 | PK58 | p58 | p58CDC2L1 | p58CLK-1cell division cycle 2-like 1 (PITSLRE proteins)CDK11-p110 interacts with 14-3-3-epsilon.BIND15883043 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)-HPRD12042314 
GPRIN2GRIN2 | KIAA0514 | MGC15171G protein regulated inducer of neurite outgrowth 2Two-hybridBioGRID16189514 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2Two-hybridBioGRID16189514 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4Affinity Capture-Western
Reconstituted Complex		BioGRID10869435 |11504882 
-HPRD11486037 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5-HPRD,BioGRID10869435 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID9111084 
IGFIR interacts with 14-3-3-epsilon isoform. This interaction is modeled on a demonstrated interaction between human IGFIR and mouse 14-3-3-epsilon isoformBIND9111084 
IRS1HIRS-1insulin receptor substrate 1IRS-1 interacts with 14-3-3-epsilon isoform. This interaction was modeled on a demonstrated interaction between human IRS-1 and mouse 14-3-3-epsilon isoform.BIND9111084 
-HPRD,BioGRID9111084 |9312143 
IRS2-insulin receptor substrate 2-HPRD,BioGRID9312143 
KCNH2ERG1 | HERG | HERG1 | Kv11.1 | LQT2 | SQT1potassium voltage-gated channel, subfamily H (eag-related), member 2-HPRD,BioGRID11953308 
KIF1CKIAA0706 | LTXS1kinesin family member 1C-HPRD10559254 
KRT18CYK18 | K18keratin 18-HPRD9524113 
MAP3K1MAPKKK1 | MEKK | MEKK1mitogen-activated protein kinase kinase kinase 1Reconstituted ComplexBioGRID9452471 
MAP3K10MLK2 | MSTmitogen-activated protein kinase kinase kinase 10-HPRD,BioGRID9427749 
MAP3K2MEKK2 | MEKK2Bmitogen-activated protein kinase kinase kinase 2-HPRD,BioGRID9452471 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD,BioGRID9452471 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD14743216 
MAPK7BMK1 | ERK4 | ERK5 | PRKM7mitogen-activated protein kinase 7Two-hybridBioGRID14679215 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 214-3-3-epsilon interacts with SMRT.BIND15494311 
NDEL1DKFZp451M0318 | EOPA | MITAP1 | NUDELnudE nuclear distribution gene E homolog (A. nidulans)-like 1-HPRD,BioGRID12796778 
NGFRAP1BEX3 | Bex | DXS6984E | HGR74 | NADEnerve growth factor receptor (TNFRSF16) associated protein 1-HPRD,BioGRID11278287 
PAPOLAMGC5378 | PAPpoly(A) polymerase alpha-HPRD14517258 
PCTK1FLJ16665 | PCTAIRE | PCTAIRE1 | PCTGAIREPCTAIRE protein kinase 1-HPRD12154078 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID7644510 
14-3-3-epsilon interacts with Raf-1.BIND7644510 
RASGRF1CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187Ras protein-specific guanine nucleotide-releasing factor 1-HPRD11533041 
REM1GD:REM | GES | MGC48669 | REMRAS (RAD and GEM)-like GTP-binding 1-HPRD,BioGRID10441394 
RGNEFDKFZp686P12164 | FLJ21817 | KIAA1998Rho-guanine nucleotide exchange factor-HPRD11533041 
RGS3C2PA | FLJ20370 | FLJ31516 | FLJ90496 | PDZ-RGS3 | RGP3regulator of G-protein signaling 3-HPRD11985497 
RIN1-Ras and Rab interactor 1-HPRD9144171 |11784866 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD10407019 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2Two-hybridBioGRID16189514 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD8702721 
SYN2SYNII | SYNIIa | SYNIIbsynapsin IITwo-hybridBioGRID10358015 
TGFB1CED | DPD1 | TGFB | TGFbetatransforming growth factor, beta 1-HPRD,BioGRID11172812 
TNFAIP3A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2tumor necrosis factor, alpha-induced protein 3-HPRD,BioGRID8702721 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDa-HPRD,BioGRID10788521 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Hamartin interacts with 14-3-3-epsilon.BIND12176984 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2-HPRD12438239 
Tumor suppressor protein tuberin interacts with 14-3-3-epsilon isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-epsilon isoform.BIND12176984 
WWTR1DKFZp586I1419 | TAZWW domain containing transcription regulator 1-HPRD11118213 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 3729All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_LIS1_PATHWAY 2822All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_P38_MK2_PATHWAY 2119All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY 4635All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY 2624All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY 3631All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_SIGNALING_BY_HIPPO 2215All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_UP 5534All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_UP 9858All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_UP 1915All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX2_DN 76All SZGR genes in this pathway
DEN_INTERACT_WITH_LCA5 2621All SZGR genes in this pathway
ZUCCHI_METASTASIS_DN 4429All SZGR genes in this pathway
MENSSEN_MYC_TARGETS 5335All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
WU_HBX_TARGETS_1_DN 2314All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
WU_HBX_TARGETS_2_UP 2313All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_DN 7945All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
SPIRA_SMOKERS_LUNG_CANCER_UP 3824All SZGR genes in this pathway
HAHTOLA_CTCL_CUTANEOUS 2619All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_UP 7253All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-155266272m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-1862272331Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-267777831Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-30-3p5605661Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-31608614m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-320216222m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-4906366421Ahsa-miR-490CAACCUGGAGGACUCCAUGCUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.