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| GeneID |
773
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| Symbol |
CACNA1A
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| Synonyms |
APCA|CACNL1A4|CAV2.1|EA2|FHM|HPCA|MHP|MHP1|SCA6
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| Description |
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit |
| See related |
HGNC:1388|MIM:601011|HPRD:03004| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
19p13.2-p13.1 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 21 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
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| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| BAT2L | 0.93 | 0.95 | | |
| GATAD2B | 0.93 | 0.93 | | |
| NAV1 | 0.93 | 0.93 | | |
| KIAA1549 | 0.93 | 0.95 | | |
| SLC7A6 | 0.93 | 0.93 | | |
| CELSR3 | 0.93 | 0.95 | | |
| CRAMP1L | 0.92 | 0.93 | | |
| MFHAS1 | 0.92 | 0.94 | | |
| ZMIZ1 | 0.92 | 0.93 | | |
| RAD54L2 | 0.92 | 0.90 | | |
Top 10 negatively co-expressed genes | | SERPINB6 | -0.68 | -0.77 | | |
| AF347015.31 | -0.66 | -0.88 | | |
| S100B | -0.66 | -0.85 | | |
| AIFM3 | -0.65 | -0.77 | | |
| C5orf53 | -0.65 | -0.76 | | |
| FXYD1 | -0.65 | -0.86 | | |
| MT-CO2 | -0.65 | -0.88 | | |
| HEPN1 | -0.65 | -0.76 | | |
| HSD17B14 | -0.65 | -0.79 | | |
| TSC22D4 | -0.64 | -0.78 | | |
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| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0019905 | syntaxin binding | IDA | Synap (GO term level: 5) | 8692999 |
| GO:0005509 | calcium ion binding | IEA | | - |
| GO:0005515 | protein binding | IPI | | 8692999 |11865310 |
| GO:0005244 | voltage-gated ion channel activity | IEA | | - |
| GO:0008331 | high voltage-gated calcium channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0007416 | synaptogenesis | IEA | Synap (GO term level: 6) | - |
| GO:0021680 | cerebellar Purkinje cell layer development | IEA | neuron, axon, Synap, dendrite (GO term level: 12) | - |
| GO:0021679 | cerebellar molecular layer development | IEA | neuron, dendrite (GO term level: 12) | - |
| GO:0021702 | cerebellar Purkinje cell differentiation | IEA | neuron, GABA, Brain (GO term level: 15) | - |
| GO:0007274 | neuromuscular synaptic transmission | IEA | neuron, Synap (GO term level: 7) | - |
| GO:0014056 | regulation of acetylcholine secretion | IEA | Neurotransmitter (GO term level: 10) | - |
| GO:0014051 | gamma-aminobutyric acid secretion | IEA | GABA, Brain, Neurotransmitter (GO term level: 10) | - |
| GO:0021590 | cerebellum maturation | IEA | Brain (GO term level: 11) | - |
| GO:0060024 | rhythmic synaptic transmission | IEA | Synap (GO term level: 8) | - |
| GO:0021953 | central nervous system neuron differentiation | IEA | neuron (GO term level: 9) | - |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | IEA | GABA, Neurotransmitter (GO term level: 8) | - |
| GO:0050770 | regulation of axonogenesis | IEA | neuron, axon (GO term level: 13) | - |
| GO:0042133 | neurotransmitter metabolic process | IEA | neuron, axon, Synap, Neurotransmitter (GO term level: 8) | - |
| GO:0043524 | negative regulation of neuron apoptosis | IEA | neuron (GO term level: 9) | - |
| GO:0048791 | calcium ion-dependent exocytosis of neurotransmitter | IEA | Synap, Neurotransmitter (GO term level: 9) | - |
| GO:0035249 | synaptic transmission, glutamatergic | IEA | neuron, glutamate, Synap, Neurotransmitter (GO term level: 8) | - |
| GO:0048813 | dendrite morphogenesis | IEA | neurite, dendrite (GO term level: 12) | - |
| GO:0000096 | sulfur amino acid metabolic process | IEA | | - |
| GO:0007204 | elevation of cytosolic calcium ion concentration | ISS | | - |
| GO:0016049 | cell growth | IEA | | - |
| GO:0008219 | cell death | IDA | | 16595610 |
| GO:0006006 | glucose metabolic process | IEA | | - |
| GO:0007628 | adult walking behavior | IEA | | - |
| GO:0006816 | calcium ion transport | IEA | | - |
| GO:0006811 | ion transport | IEA | | - |
| GO:0050885 | neuromuscular process controlling balance | IEA | | - |
| GO:0050883 | musculoskeletal movement, spinal reflex action | IEA | | - |
| GO:0032353 | negative regulation of hormone biosynthetic process | IEA | | - |
| GO:0042403 | thyroid hormone metabolic process | IEA | | - |
| GO:0048266 | behavioral response to pain | IEA | | - |
| GO:0030644 | cellular chloride ion homeostasis | IEA | | - |
| GO:0043113 | receptor clustering | IEA | | - |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | IEA | | - |
| GO:0021750 | vestibular nucleus development | IEA | | - |
| GO:0051899 | membrane depolarization | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0043025 | cell soma | IEA | axon, dendrite (GO term level: 4) | - |
| GO:0042995 | cell projection | IDA | axon (GO term level: 4) | 16595610 |
| GO:0030425 | dendrite | IEA | neuron, axon, dendrite (GO term level: 6) | - |
| GO:0005634 | nucleus | IDA | | 16595610 |
| GO:0005737 | cytoplasm | IDA | | 16595610 |
| GO:0016021 | integral to membrane | TAS | | 16595610 |
| GO:0005886 | plasma membrane | EXP | | 8825650 |
| GO:0005886 | plasma membrane | IDA | | 16595610 |
| GO:0005891 | voltage-gated calcium channel complex | IEA | | - |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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