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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: NCOA3

Summary

GeneID

8202

Symbol

NCOA3

Synonyms

ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|MGC141848|RAC3|SRC3|TNRC14|TNRC16|TRAM-1|pCIP

Description

nuclear receptor coactivator 3

Locus tag

RP5-1049G16.3

Gene type

protein-coding

Map location

20q12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 2.056

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0397

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004871

signal transducer activity

IEA

GO:0003713

transcription coactivator activity

NAS

9267036 |15572661

GO:0004402

histone acetyltransferase activity

TAS

GO:0016740

transferase activity

IEA

GO:0008415

acyltransferase activity

IEA

GO:0030528

transcription regulator activity

IEA

GO:0047485

protein N-terminus binding

IPI

12917342

GO:0050681

androgen receptor binding

NAS

15572661

GO:0046966

thyroid hormone receptor binding

NAS

9267036 |9346901

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007165

signal transduction

IEA

GO:0030521

androgen receptor signaling pathway

NAS

15572661

GO:0045893

positive regulation of transcription, DNA-dependent

NAS

15572661

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

NAS

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	Reconstituted Complex Two-hybrid	BioGRID	15184363
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	ANCO-1 interacts with RAC3.	BIND	15184363
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	10965917
BMP6	VGR \| VGR1	bone morphogenetic protein 6	-	HPRD	10504300
BMP7	OP-1	bone morphogenetic protein 7	-	HPRD	7791754
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Protein-peptide	BioGRID	14578343
CARM1	PRMT4	coactivator-associated arginine methyltransferase 1	SRC-3 interacts with CARM1. This interaction was modelled on a demonstrated interaction between human SRC-3 and CARM1 from an unspecified species.	BIND	15383283
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD,BioGRID	9832502
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	AIB1 interacts with cyclin D1 promoter.	BIND	15808510
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	11971985
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Affinity Capture-MS Co-fractionation Two-hybrid	BioGRID	11076796 \|11971985
			ACTR interacts with CBP. This interaction was modeled on a demonstrated interaction between human ACTR and CBP from an unspecified species.	BIND	9267036
			SRC-3 interacts with CBP. This interaction was modelled on a demonstrated interaction between human SRC-3 and CBP from an unspecified species.	BIND	15383283
			CBP interacts with TRAM-1. This interaction was modelled on a demonstrated interaction between mouse CBP and human TRAM-1.	BIND	9346901
			-	HPRD	9445475 \|11823864
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	ACTR interacts with E2F1.	BIND	15169882
EBAG9	EB9 \| PDAF \| RCAS1	estrogen receptor binding site associated, antigen, 9	AIB1 interacts with EBAG9 promoter.	BIND	15808510
EP300	KAT3B \| p300	E1A binding protein p300	Affinity Capture-Western	BioGRID	10655477
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	NCOA3 (AIB1) interacts with the ERBB2 (HER2) promoter.	BIND	15788656
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD,BioGRID	11050174
			SRC-3 interacts with ER. This interaction was modelled on a demonstrated interaction between human SRC-3 and ER from an unspecified species.	BIND	15383283
			TRAM-1 interacts with ER.	BIND	9346901
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD,BioGRID	10681591 \|11389589
ESRRA	ERR1 \| ERRa \| ERRalpha \| ESRL1 \| NR3B1	estrogen-related receptor alpha	Reconstituted Complex	BioGRID	10598588
ESRRB	DFNB35 \| ERR2 \| ERRb \| ERRbeta \| ERRbeta-2 \| ESRL2 \| NR3B2	estrogen-related receptor beta	-	HPRD,BioGRID	10598588
ETS1	ETS-1 \| EWSR2 \| FLJ10768	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	NCOA3 (AIB1) interacts with ETS1.	BIND	15788656
ETS2	ETS2IT1	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	NCOA3 (AIB1) interacts with ETS2.	BIND	15788656
ETV1	DKFZp781L0674 \| ER81 \| MGC104699 \| MGC120533 \| MGC120534	ets variant 1	ACTR interacts with ER81.	BIND	14747462
GSK3B	-	glycogen synthase kinase 3 beta	SRC-3 interacts with and is phosphorylated by GSK3-beta.	BIND	15383283
GTF2B	TF2B \| TFIIB	general transcription factor IIB	-	HPRD	9267036
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD,BioGRID	11971985
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	Affinity Capture-MS Affinity Capture-Western Co-fractionation Reconstituted Complex	BioGRID	11971985
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	P/CAF interacts with TRAM-1.	BIND	9346901
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	-	HPRD	9445475
MMS19	FLJ34167 \| FLJ95146 \| MET18 \| MGC99604 \| MMS19L \| hMMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	-	HPRD	11279242
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	AIB1 interacts with c-myc promoter.	BIND	15808510
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	Affinity Capture-MS	BioGRID	11971985
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	-	HPRD	9267036
NKX2-1	BCH \| BHC \| NK-2 \| NKX2.1 \| NKX2A \| TEBP \| TITF1 \| TTF-1 \| TTF1	NK2 homeobox 1	Two-hybrid	BioGRID	11076796
NPAS2	FLJ23138 \| MGC71151 \| MOP4 \| PASD4 \| bHLHe9	neuronal PAS domain protein 2	-	HPRD,BioGRID	14645221
NR0B2	FLJ17090 \| SHP \| SHP1	nuclear receptor subfamily 0, group B, member 2	Two-hybrid	BioGRID	11668176
NR2F1	COUP-TFI \| EAR-3 \| EAR3 \| ERBAL3 \| NR2F2 \| SVP44 \| TCFCOUP1 \| TFCOUP1	nuclear receptor subfamily 2, group F, member 1	Two-hybrid	BioGRID	10652338
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Affinity Capture-Western Reconstituted Complex	BioGRID	11266503 \|12917342
NR4A1	GFRP1 \| HMR \| MGC9485 \| N10 \| NAK-1 \| NGFIB \| NP10 \| NUR77 \| TR3	nuclear receptor subfamily 4, group A, member 1	-	HPRD,BioGRID	12082103
NR5A2	B1F \| B1F2 \| CPF \| FTF \| FTZ-F1 \| FTZ-F1beta \| LRH-1 \| hB1F \| hB1F-2	nuclear receptor subfamily 5, group A, member 2	NR5A2 interacts with an unspecified isoform of NCOA3.	BIND	15723037
NR5A2		nuclear receptor subfamily 5, group A, member 2	Two-hybrid	BioGRID	11668176
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	RAC3 interacts with PPAR-alpha. This interaction was modelled on a demonstrated interaction between human RAC3 and mouse PPAR-alpha.	BIND	9238002
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	Reconstituted Complex Two-hybrid	BioGRID	10944516
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	-	HPRD,BioGRID	11050077
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	RAC3 interacts with RAR-alpha.	BIND	9238002
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	SRC-3 interacts with NF-kappa-B.	BIND	15383283
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	ACTR interacts with RXR.	BIND	9267036
RXRA		retinoid X receptor, alpha	-	HPRD,BioGRID	9267036
RXRB	DAUDI6 \| H-2RIIBP \| MGC1831 \| NR2B2 \| RCoR-1	retinoid X receptor, beta	TRAM-1 interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and mouse RXR-beta.	BIND	9346901
RXRB	DAUDI6 \| H-2RIIBP \| MGC1831 \| NR2B2 \| RCoR-1	retinoid X receptor, beta	-	HPRD	9267036
SMARCE1	BAF57	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	-	HPRD	12145209
SUFU	PRO1280 \| SUFUH \| SUFUXL	suppressor of fused homolog (Drosophila)	-	HPRD	14611647
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	-	HPRD	9267036
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	TRAM-1 interacts with TR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and rat TR-beta.	BIND	9346901
THRB			ACTR interacts with TR.	BIND	9267036
TRIM21	RNF81 \| RO52 \| SSA \| SSA1	tripartite motif-containing 21	Affinity Capture-MS	BioGRID	11971985
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	ACTR interacts with VDR.	BIND	9267036
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD	11266503
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Reconstituted Complex	BioGRID	11266503

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	2596	2602	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	777	783	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-137	869	875	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-17-5p/20/93.mr/106/519.d	1296	1302	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-24*	1254	1260	m8	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-29	2314	2320	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-33	739	745	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	739	745	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-369-3p	990	996	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-378	3261	3267	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-495	1300	1306	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-9	2733	2739	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.