Gene Page: DGCR14

Summary
GeneID  8220
Symbol  DGCR14
Synonyms  DGCR13|DGS-H|DGS-I|DGSH|DGSI|ES2|Es2el
Description  DiGeorge syndrome critical region gene 14
See related  HGNC:16817|MIM:601755|Ensembl:ENSG00000100056|HPRD:03452|HPRD:18586|
Locus tag  -
Gene type  protein-coding
Map location  22q11.21|22q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BCKDK0.830.81
SLC35A40.830.84
MFSD50.820.81
CRAT0.810.78
PQLC20.810.83
PIGQ0.810.80
SLC5A20.800.77
HSD17B10.800.79
TESK10.790.81
B4GALT70.790.78
Top 10 negatively co-expressed genes
AF347015.21-0.58-0.57
AF347015.31-0.55-0.50
MT-ATP8-0.52-0.57
AF347015.8-0.52-0.50
MT-CO2-0.52-0.48
AF347015.27-0.52-0.49
MT-CYB-0.50-0.47
AF347015.33-0.47-0.44
AF347015.2-0.47-0.44
AL139819.3-0.47-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentISSneurite (GO term level: 5)8703114 
GO:0006397mRNA processingIEA-
GO:0008380RNA splicingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS8703114 
GO:0005681spliceosomeIEA-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
LYSTCHS | CHS1lysosomal trafficking regulator-HPRD,BioGRID11984006 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_DN 3518All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_DN 2019All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
LI_DCP2_BOUND_MRNA 8957All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50616161622m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/30120602066m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-205194119471Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2624202426m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-324-5p22252231m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-335193719431Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-378*20932099m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-505234923551Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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