Gene Page: DOCK7

Summary
GeneID  85440
Symbol  DOCK7
Synonyms  KIAA1771|ZIR2
Description  dedicator of cytokinesis 7
See related  HGNC:19190|Ensembl:ENSG00000116641|HPRD:16833|
Locus tag  -
Gene type  protein-coding
Map location  1p31.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02692 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005525GTP bindingIEA-
GO:0051020GTPase bindingIEA-
GO:0048365Rac GTPase bindingIDA16982419 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisIMPneuron, axon, neurite (GO term level: 12)16982419 
GO:0031175neurite developmentIMPneuron, axon, neurite, dendrite (GO term level: 10)16982419 
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0000226microtubule cytoskeleton organizationIMP16982419 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0033138positive regulation of peptidyl-serine phosphorylationIMP16982419 
GO:0032863activation of Rac GTPase activityIDA16982419 
GO:0045200establishment of neuroblast polarityIMP16982419 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030426growth coneTASaxon, dendrite (GO term level: 5)16982419 
GO:0030424axonTASneuron, axon, Neurotransmitter (GO term level: 6)16982419 
GO:0045178basal part of cellTAS16982419 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD12432077 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member A-HPRD12432077 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Affinity Capture-MSBioGRID15963462 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ERBB2_ERBB3_PATHWAY 4435All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP 6229All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_UP 4932All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-181388394m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-233853911Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p3923991A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-543389395m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.