Gene Page: EIF4EBP3

Summary
GeneID  8637
Symbol  EIF4EBP3
Synonyms  4E-BP3
Description  eukaryotic translation initiation factor 4E binding protein 3
See related  HGNC:3290|MIM:603483|Ensembl:ENSG00000131503|HPRD:09149|
Locus tag  -
Gene type  protein-coding
Map location  5q31.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1475 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM49A0.870.90
SHOC20.850.89
FAM135A0.840.89
WDR470.830.86
AASDHPPT0.830.86
NELL20.830.87
PPAPR50.830.84
ATF20.830.84
RAP2A0.820.85
CLASP20.820.87
Top 10 negatively co-expressed genes
MT-CO2-0.67-0.71
FXYD1-0.67-0.72
HSD17B14-0.66-0.71
AF347015.33-0.65-0.67
MT-CYB-0.65-0.68
AF347015.8-0.65-0.70
AF347015.31-0.64-0.68
C11orf67-0.64-0.69
ACSF2-0.63-0.71
AF347015.26-0.63-0.66
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI15153109 
GO:0008190eukaryotic initiation factor 4E bindingIEA-
GO:0030371translation repressor activityNAS9593750 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045947negative regulation of translational initiationNAS9593750 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016281eukaryotic translation initiation factor 4F complexNAS9593750 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF4ECBP | EIF4E1 | EIF4EL1 | EIF4F | MGC111573eukaryotic translation initiation factor 4E-HPRD,BioGRID12482586 
EIF4E24E-LP | 4EHP | EIF4EL3 | IF4eeukaryotic translation initiation factor 4E family member 2Two-hybridBioGRID16189514 
 
Pathway annotation
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1881631691Ahsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-4211481541Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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