Gene Page: IQGAP1

Summary
GeneID  8826
Symbol  IQGAP1
Synonyms  HUMORFA01|KIAA0051|SAR1|p195
Description  IQ motif containing GTPase activating protein 1
See related  HGNC:6110|MIM:603379|Ensembl:ENSG00000140575|HPRD:04541|
Locus tag  -
Gene type  protein-coding
Map location  15q26.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.019 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TMEM680.800.80
UBA30.780.78
DCK0.780.79
SCCPDH0.770.79
IDI10.770.78
FBXO30.770.79
LRRC400.770.78
EXOC60.770.81
TMEM50A0.770.76
BIRC20.770.77
Top 10 negatively co-expressed genes
MT-CO2-0.61-0.59
AF347015.26-0.58-0.60
AF347015.8-0.58-0.57
AF347015.2-0.57-0.58
AF347015.33-0.57-0.56
MT-CYB-0.57-0.56
AF347015.15-0.56-0.56
FXYD1-0.55-0.55
AF347015.31-0.55-0.56
AF347015.21-0.54-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005095GTPase inhibitor activityTAS8670801 
GO:0005099Ras GTPase activator activityIEA-
GO:0005516calmodulin bindingTAS8670801 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS8051149 
GO:0051056regulation of small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
GO:0005884actin filamentTAS8670801 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD,BioGRID12938160 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAPC interacts with IQGAP1.BIND15572129 
ARF6DKFZp564M0264ADP-ribosylation factor 6Affinity Capture-MSBioGRID17353931 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)Reconstituted ComplexBioGRID11734550 |12446675 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD8670801 |12900413|8798539 
|9182573 
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex		BioGRID8670801 |8798539 
|9182573 |12110184 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD,BioGRID10608854 
CLIC5CLIC5B | FLJ90663 | MST130 | MSTP130 | dJ447E21.4chloride intracellular channel 5-HPRD10793131 
CLIP1CLIP | CLIP-170 | CLIP170 | CYLN1 | MGC131604 | RSNCAP-GLY domain containing linker protein 1IQGAP1 interacts with CLIP-170. This interaction was modeled on a demonstrated interaction between IQGAP1 and CLIP-170, both from African green monkey.BIND15572129 
-HPRD,BioGRID12110184 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD,BioGRID11734550|12446675 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinReconstituted ComplexBioGRID10793131 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MSBioGRID12577067 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alphaAffinity Capture-Western
Co-purification		BioGRID12938160 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID8670801 
S100BNEF | S100 | S100betaS100 calcium binding protein B-HPRD,BioGRID12377780 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-122110116m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-124.1866872m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5068658721A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-4109249301Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-485-3p209521021A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.