Gene Page: CDK5R1

Summary
GeneID  8851
Symbol  CDK5R1
Synonyms  CDK5P35|CDK5R|MGC33831|NCK5A|p23|p25|p35|p35nck5a
Description  cyclin-dependent kinase 5, regulatory subunit 1 (p35)
See related  HGNC:1775|MIM:603460|Ensembl:ENSG00000176749|HPRD:04586|
Locus tag  -
Gene type  protein-coding
Map location  17q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 14 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LTV10.840.83
MED40.840.81
PARP20.840.80
RAD170.830.81
EXOC10.830.81
USP160.820.81
UBA50.820.80
GTF2H10.820.79
HERC40.820.79
DNAJC100.820.80
Top 10 negatively co-expressed genes
MT-CO2-0.75-0.63
AF347015.2-0.73-0.62
AF347015.21-0.73-0.59
AF347015.31-0.73-0.63
AF347015.8-0.73-0.62
MT-CYB-0.72-0.60
AF347015.15-0.70-0.61
AF347015.33-0.69-0.57
AF347015.27-0.68-0.58
HIGD1B-0.68-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingISS-
GO:0005515protein bindingIPI10721722 |12223541 
GO:0005515protein bindingISS-
GO:0004672protein kinase activityTAS7592934 
GO:0016534cyclin-dependent protein kinase 5 activator activityIEA-
GO:0045296cadherin bindingISS-
GO:0043539protein serine/threonine kinase activator activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentISSBrain (GO term level: 7)-
GO:0007420brain developmentNASBrain (GO term level: 7)10915792 
GO:0007413axonal fasciculationISSneuron, axon (GO term level: 13)-
GO:0007411axon guidanceISSaxon (GO term level: 13)-
GO:0001764neuron migrationISSneuron (GO term level: 8)-
GO:0031175neurite developmentISSneuron, axon, neurite, dendrite (GO term level: 10)-
GO:0007158neuron adhesionISSneuron (GO term level: 5)-
GO:0045664regulation of neuron differentiationNASneuron, neurogenesis (GO term level: 9)10721722 
GO:0043525positive regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0035235ionotropic glutamate receptor signaling pathwayISSglutamate (GO term level: 8)-
GO:0000079regulation of cyclin-dependent protein kinase activityTAS7592934 
GO:0007213acetylcholine receptor signaling, muscarinic pathwayISS-
GO:0008283cell proliferationTAS8090221 
GO:0009790embryonic developmentISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaISSaxon, dendrite (GO term level: 4)-
GO:0031594neuromuscular junctionISSneuron, axon, Synap, Neurotransmitter (GO term level: 3)-
GO:0043197dendritic spineISSSynap, dendrite (GO term level: 7)-
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0030424axonISSneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-
GO:0005886plasma membraneIEA-
GO:0016533cyclin-dependent protein kinase 5 activator complexIEA-
GO:0043292contractile fiberISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN1FLJ40884actinin, alpha 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12223541 
AMPHAMPH1amphiphysinAmphiphysin 1 interacts with p35. This interaction was modeled on a demonstrated interaction between human amphiphysin 1 and rat p35.BIND11113134 
-HPRD,BioGRID11113134 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alpha-HPRD,BioGRID12223541 
CDK5PSSALREcyclin-dependent kinase 5p35 interacts with Cdk5. This interaction was modeled on a demonstrated interaction between bovine p35 and human Cdk5.BIND9038181 
-HPRD,BioGRID11583627 
Cdk5 interacts with p35.BIND8090221 
CDK5R1CDK5P35 | CDK5R | MGC33831 | NCK5A | p23 | p25 | p35 | p35nck5acyclin-dependent kinase 5, regulatory subunit 1 (p35)-HPRD11389014 
CDK5RAP1C20orf34 | C42 | CDK5RAP1.3 | CDK5RAP1.4 | CGI-05 | HSPC167CDK5 regulatory subunit associated protein 1-HPRD,BioGRID10721722 |10915792 
|11882646 
-HPRD11882646 
CDK5RAP2C48 | Cep215 | DKFZp686B1070 | DKFZp686D1070 | KIAA1633 | MCPH3CDK5 regulatory subunit associated protein 2in vitro
in vivo
Reconstituted Complex		BioGRID10915792 |11882646 
-HPRD10721722 
CDK5RAP3C53 | HSF-27 | IC53 | LZAP | MST016 | OK/SW-cl.114CDK5 regulatory subunit associated protein 3-HPRD10721722 |10915792 
-HPRD,BioGRID11882646 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9-HPRD12037672 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-Western
Reconstituted Complex		BioGRID11168528 
LMTK2AATYK2 | BREK | KIAA1079 | KPI-2 | KPI2 | LMR2 | cprklemur tyrosine kinase 2-HPRD12832520 
NESFLJ21841 | Nbla00170nestin-HPRD12832492 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD11604394 
PCTK1FLJ16665 | PCTAIRE | PCTAIRE1 | PCTGAIREPCTAIRE protein kinase 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12084709 
SET2PP2A | I2PP2A | IGAAD | IPP2A2 | PHAPII | TAF-I | TAF-IBETASET nuclear oncogene-HPRD,BioGRID11741927 
TSC22D4THG-1 | THG1TSC22 domain family, member 4Two-hybridBioGRID16189514 
TTBK1BDTK | KIAA1855 | RP3-330M21.4tau tubulin kinase 1-HPRD7556643 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
BIOCARTA_P35ALZHEIMERS_PATHWAY 119All SZGR genes in this pathway
BIOCARTA_CDK5_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_RAC1_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY 1717All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_LIS1_PATHWAY 2822All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_CRMPS_IN_SEMA3A_SIGNALING 1414All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP 2920All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
KIM_MYCL1_AMPLIFICATION_TARGETS_UP 1311All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_UP 5340All SZGR genes in this pathway
STARK_BRAIN_22Q11_DELETION 1310All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_DN 6038All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_UP 4334All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP 3426All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10126732679m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/10720942100m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-148/152269527021A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497209521021A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-18324042410m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-208221122171Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-23131513221A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-27148114871Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-323131513211Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3622430m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-376210021061Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-433-3p261526211Ahsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-499221122171Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-503209621021Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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