Gene Page: EIF2B5

Summary
GeneID  8893
Symbol  EIF2B5
Synonyms  CACH|CLE|EIF-2B|EIF2Bepsilon|LVWM
Description  eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
See related  HGNC:3261|MIM:603945|Ensembl:ENSG00000145191|HPRD:04898|
Locus tag  -
Gene type  protein-coding
Map location  3q27.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIDA11323413 
GO:0005085guanyl-nucleotide exchange factor activityIMP15054402 
GO:0005085guanyl-nucleotide exchange factor activityISS-
GO:0003743translation initiation factor activityIDA16289705 
GO:0003743translation initiation factor activityNAS8688466 
GO:0005515protein bindingIPI15060152 
GO:0005515protein bindingISS-
GO:0016740transferase activityIEA-
GO:0008415acyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0014003oligodendrocyte developmentIMPaxon, oligodendrocyte, Glial (GO term level: 10)15217090 
GO:0014002astrocyte developmentIMPneuron, astrocyte, Glial (GO term level: 10)15723074 
GO:0042552myelinationIMPneuron, axon, Brain, oligodendrocyte (GO term level: 13)14566705 |15723074 
GO:0001541ovarian follicle developmentIMP15507143 
GO:0009408response to heatIMP15723074 
GO:0009408response to heatISS-
GO:0009408response to heatTAS12499492 
GO:0009749response to glucose stimulusISS-
GO:0043434response to peptide hormone stimulusISS-
GO:0045948positive regulation of translational initiationISS-
GO:0051716cellular response to stimulusIDA8626696 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005851eukaryotic translation initiation factor 2B complexIDA11323413 |15060152 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA11323413 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF2B1EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDaAffinity Capture-MS
Reconstituted Complex		BioGRID10858531 |17353931 
EIF2B2EIF-2Bbeta | EIF2Beukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa-HPRD,BioGRID10858531 
EIF2B3EIF-2B | EIF2Bgammaeukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDaReconstituted ComplexBioGRID10858531 
-HPRD10805739 
EIF2B4DKFZp586J0119 | EIF-2B | EIF2B | EIF2Bdeltaeukaryotic translation initiation factor 2B, subunit 4 delta, 67kDaReconstituted ComplexBioGRID10858531 
-HPRD9446619 |10805739 
EIF2S2DKFZp686L18198 | EIF2 | EIF2B | EIF2beta | MGC8508eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa-HPRD9446619 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_EIF2_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_IGF1MTOR_PATHWAY 2014All SZGR genes in this pathway
BIOCARTA_VEGF_PATHWAY 2918All SZGR genes in this pathway
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP 8443All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-200bc/429136142m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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