Gene Page: HERC2

Summary
GeneID  8924
Symbol  HERC2
Synonyms  D15F37S1|DKFZp547P028|KIAA0393|SHEP1|jdf2|p528
Description  hect domain and RLD 2
See related  HGNC:4868|MIM:605837|Ensembl:ENSG00000128731|HPRD:06905|
Locus tag  -
Gene type  protein-coding
Map location  15q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0114 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CCNT20.950.96
ZNF3180.930.95
OGT0.930.95
C10orf180.930.96
BRWD10.930.94
MED230.930.95
ZNF6380.930.94
RBM12B0.930.96
ZNF2480.930.95
KIAA09470.920.95
Top 10 negatively co-expressed genes
FXYD1-0.76-0.85
AF347015.31-0.75-0.84
MT-CO2-0.74-0.85
IFI27-0.74-0.85
HIGD1B-0.73-0.86
AF347015.33-0.71-0.79
ENHO-0.70-0.83
S100B-0.70-0.78
TSC22D4-0.70-0.76
CST3-0.70-0.83
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityNAS9949213 
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004672protein kinase activityIEA-
GO:0016874ligase activityIEA-
GO:0016881acid-amino acid ligase activityIEA-
GO:0020037heme bindingIEA-
GO:0008270zinc ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006464protein modification processIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006886intracellular protein transportNAS9949213 
GO:0030071regulation of mitotic metaphase/anaphase transitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005622intracellularIEA-
GO:0005680anaphase-promoting complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DBNLABP1 | HIP-55 | SH3P7drebrin-likeAffinity Capture-MSBioGRID17353931 
MPDU1CDGIF | FLJ14836 | HBEBP2BPA | Lec35 | PQLC5 | SL15mannose-P-dolichol utilization defect 1Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
LEE_RECENT_THYMIC_EMIGRANT 227128All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1072312381A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-25/32/92/363/367334340m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p254260m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-369-3p4204271A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3744214281A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-5003333391Ahsa-miR-500AUGCACCUGGGCAAGGAUUCUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.