Gene Page: PHOX2B

Summary
GeneID  8929
Symbol  PHOX2B
Synonyms  NBPhox|PMX2B
Description  paired-like homeobox 2b
See related  HGNC:9143|MIM:603851|Ensembl:ENSG00000109132|HPRD:09157|
Locus tag  -
Gene type  protein-coding
Map location  4p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM96B0.920.91
EXOSC40.910.91
PSMB30.910.89
EXOSC50.910.90
C12orf100.900.89
NOSIP0.900.88
SF3B50.900.88
PSMB40.890.88
ANAPC110.890.85
CUEDC20.890.88
Top 10 negatively co-expressed genes
AF347015.26-0.54-0.57
AF347015.18-0.50-0.56
AF347015.8-0.50-0.50
AF347015.15-0.50-0.52
MT-ATP8-0.49-0.54
AF347015.2-0.49-0.51
MT-CYB-0.48-0.51
AF347015.27-0.48-0.52
AF347015.33-0.48-0.51
ANKRD18B-0.45-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS10395798 
GO:0003712transcription cofactor activityTAS10395798 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)10395798 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0048468cell developmentIEA-
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_RUNX1 96All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_DN 12069All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MIKKELSEN_PARTIALLY_REPROGRAMMED_TO_PLURIPOTENCY 106All SZGR genes in this pathway
MIKKELSEN_IPS_WITH_HCP_H3K27ME3 10276All SZGR genes in this pathway
MIKKELSEN_ES_HCP_WITH_H3K27ME3 4130All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/351323329m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-13810021008m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-146144414501Ahsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-18112851291m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-32010051011m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-494158415911A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-495150515111Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-50015141520m8hsa-miR-500AUGCACCUGGGCAAGGAUUCUG
miR-54312861292m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-799710031Ahsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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